Actively Recruiting
Study of Galectin-3 Levels and Their Link to Post-Operative Atrial Fibrillation After Coronary Artery Bypass Graft Surgery
Led by University of Sao Paulo General Hospital · Updated on 2025-01-10
90
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the relationship between high levels of Galectin-3 and the development of post-operative atrial fibrillation in patients undergoing coronary artery bypass graft (CABG) surgery. This observational study aims to determine if Galectin-3 can serve as an accurate biomarker for predicting higher risk of post-operative atrial fibrillation and whether elevated levels are linked to other complications and major cardiovascular events after surgery. Participants will be enrolled during their pre-operative evaluation, where a peripheral blood sample will be taken within 24 hours before the CABG surgery to measure Galectin-3 levels. After surgery, patients will be monitored daily during their hospital stay and followed for 12 months with three appointments after discharge to assess their outcomes. Throughout the study, researchers will collect data on the presence of post-operative atrial fibrillation and other complications. They will perform ongoing evaluations during hospitalization and follow-up visits, measuring Galectin-3 levels and recording cardiovascular events. The primary outcome measured is the occurrence of post-operative atrial fibrillation up to 7 days after surgery, with extended monitoring to assess longer-term health outcomes over the 12-month follow-up period.
CONDITIONS
Official Title
Association Between GalectiN-3 and POSt-operative AtrIal Fibrillation After Coronary Artery BypaSs Graft
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing coronary artery bypass graft surgery
You will not qualify if you...
- Unable to sign informed consent
- Renal dysfunction with estimated glomerular filtration rate less than 30 ml/min/1.73m² or on dialysis
- Moderate to severe left ventricular dysfunction (ejection fraction < 40%)
- History of atrial fibrillation
- Pregnancy
- Undergoing valve surgery along with CABG
AI-Screening
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Trial Site Locations
Total: 1 location
1
Instituto do Coração - Hospital das Clínicas - Faculdade de Medicina da Universidade de São Paulo
São Paulo, São Paulo, Brazil, 05403000
Actively Recruiting
Research Team
E
Eduardo Lima
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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