Actively Recruiting
Association Between Galectin-3 and Post-operative Atrial Fibrillation After Coronary Artery Bypass Graft
Led by University of Sao Paulo General Hospital · Updated on 2025-01-10
90
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to explore the relationship between high levels of Galectin-3 and the risk of developing post-operative atrial fibrillation after isolated coronary artery bypass grafting (CABG). It also evaluates whether elevated Galectin-3 levels are linked to other post-operative complications and major adverse cardiovascular events. The study is observational and includes patients undergoing CABG surgery. Participants will be enrolled during their preoperative evaluation. A peripheral blood sample will be taken within 24 hours before the CABG surgery to measure Galectin-3 levels. Patients will then be followed daily during hospitalization and through three follow-up appointments after discharge, for a total follow-up period of 12 months. During the study, researchers will monitor whether participants develop atrial fibrillation within 7 days after surgery and assess other complications at 6 weeks. They will also track major cardiovascular events and changes in the heart's left atrium structure over 12 months. The study involves blood sample collection, health assessments during hospital stay, and scheduled follow-up visits to gather comprehensive outcome data.
CONDITIONS
Brief Title
Association Between GalectiN-3 and POSt-operative AtrIal Fibrillation After Coronary Artery BypaSs Graft
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing coronary artery bypass graft surgery
You will not qualify if you...
- Inability to sign the free and informed consent form
- Renal dysfunction with estimated glomerular filtration rate less than 30ml / min / 1.73m² or dialysis therapy
- Moderate to severe left ventricular dysfunction (ejection fraction < 40%)
- Patients with previous atrial fibrillation
- Pregnancy
- Concomitant valve surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) during preoperative evaluation
Duration - 1 day
Participants provide a peripheral blood sample within 24 hours before coronary artery bypass graft surgery.
1 visit (in-person) for blood sample collection
Duration - Up to 7 days
Participants undergo coronary artery bypass graft surgery and are monitored during hospitalization for post-operative atrial fibrillation and other complications.
Hospitalization period with continuous monitoring
Duration - 12 months
Participants are followed after discharge to assess cardiovascular events and heart remodeling.
Follow-up visits over 12 months after discharge
Trial Site Locations
Total: 1 location
1
Instituto do Coração - Hospital das Clínicas - Faculdade de Medicina da Universidade de São Paulo
São Paulo, São Paulo, Brazil, 05403000
Actively Recruiting
Research Team
E
Eduardo Lima
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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