Actively Recruiting
Association Between Health Care Provider (HCP)-Assessed ECOG Performance Status (PS) and Overall Survival, and Objectively Measure of Physical Activity (PA) Levels in Advance-cancer Patients"
Led by M.D. Anderson Cancer Center · Updated on 2026-01-07
590
Participants Needed
1
Research Sites
840 weeks
Total Duration
On this page
Sponsors
M
M.D. Anderson Cancer Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The main goal of this phase of the study is to determine if objectively assessed Physical Activity (PA) levels in advanced-cancer patients are associated with health care provider (HCP)-assessed ECOG performance status and overall survival. The purpose is to advance the evidence-base for incorporating objective assessment of Physical Activity (PA) in the context of performance status assessment in advanced cancer patients.
CONDITIONS
Official Title
Association Between Health Care Provider (HCP)-Assessed ECOG Performance Status (PS) and Overall Survival, and Objectively Measure of Physical Activity (PA) Levels in Advance-cancer Patients"
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of any stage I - IV colorectal cancer or recurrent colorectal cancer (Arm 1)
- Able to speak, read, and write in English (Pre-pilot phase, Arms 1-4)
- Able to provide informed consent (Pre-pilot phase, Arms 1-4, PCS study)
- Lives in the Houston area (Harris county or contiguous county) (Pre-pilot phase)
- Eastern Cooperative Oncology Group (ECOG) status of 0 - 2, or self-reports being up and about more than 50% of waking hours and able to provide self-care (Arm 1)
- Diagnosis of stage 1-4b oropharyngeal, hypopharyngeal, nasopharyngeal, salivary gland or oral cavity cancer; stage 3-4b laryngeal cancer; unknown primary head and neck cancer with cervical metastasis treated to bilateral necks and mucosa; or other head and neck cancers approved by Radiation Oncology MDs (Arms 2 and 3)
- History of any cancer, excluding non-melanoma skin cancer (Arm 4)
- Admitted current smoker or recent quitter at MD Anderson Cancer Center (Arm 4)
- Valid home address and functioning home telephone number (Arm 4)
- Lives in Houston or surrounding area during study period (Arms 1-4)
- Patients undergoing curative pancreatectomy for pancreatic adenocarcinoma, neuroendocrine tumors, or cysts (PCS study)
- Fluent in English (PCS and TAPS studies)
- Telephone access and willingness to engage with research personnel by phone (PCS study)
- Diagnosis of metastatic or locally unresectable solid tumor (TAPS study)
- Age 18 or older (TAPS study)
- ECOG performance status 0-3 (TAPS study)
You will not qualify if you...
- Major surgery within past 8 weeks (Arms 1 and 4)
- Self-reported hypertension not monitored or managed (Pre-pilot, Arms 1-3)
- Overt cognitive difficulty, not oriented to time, person, or place (Arms 1-4, TAPS study)
- Orthopedic, neurologic, or musculoskeletal disability interfering with standing on weight scale (Pre-pilot, Arm 2)
- Not currently receiving radiation treatment for eligible cancer (Arms 2 and 3)
- Zubrod performance status greater than 2, or self-reports not being up and about more than 50% of waking hours or unable to provide self-care (Arms 2 and 3)
- Currently treated for cancer other than those listed (except non-melanoma skin cancer) (Arms 2 and 3)
- History of oropharyngeal dysphagia unrelated to cancer (Arm 3 only)
- Active substance use disorder (diagnosed or suspected) (Arm 4)
- Currently enrolled in protocol 2014-0712 (PCS study)
- No home internet or WiFi access (PCS study)
- High risk for non-therapeutic resection during pre-surgical evaluation (PCS study)
- Unstable cardiac or pulmonary disease or symptomatic cardiac disease NYHA class III or IV (PCS study)
- Recent fracture or acute musculoskeletal injury preventing full weight bearing (PCS study)
- Poorly controlled pain with score 7/10 at enrollment (PCS study)
- Myopathic or rheumatologic disease affecting physical function (PCS study)
- Has pacemaker, other internal medical device, or is pregnant (PCS study)
- Currently enrolled in protocol 2017-0198 (PCS study)
AI-Screening
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Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
S
Susan Peterson
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
6
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