Actively Recruiting
Association of Microplastic Exposure With Pathological Stages of Gastric Mucosal Carcinogenesis: A Cross-Sectional Study
Led by Yongquan Shi · Updated on 2026-04-30
450
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the link between the amount of microplastic exposure and the risk of developing gastric mucosal carcinogenesis, which includes conditions like chronic non-atrophic gastritis, precancerous lesions, and gastric cancer. The study aims to understand whether higher microplastic exposure increases this risk and to identify sources of high-risk microplastic exposure. Participants will complete a detailed questionnaire about their exposure to external microplastics to help answer these questions. Participants will be divided into three groups based on their medical diagnosis from endoscopic or histopathological results: those with chronic non-atrophic gastritis, those with precancerous lesions such as chronic atrophic gastritis or gastric intestinal metaplasia, and those diagnosed with gastric cancer. The study will record demographic information, Helicobacter pylori infection status, and plastic exposure scores for each participant group. During the study, participants will provide information through the structured questionnaire and undergo testing to confirm Helicobacter pylori status. Researchers will analyze the correlation between microplastic exposure and the stages of gastric mucosal carcinogenesis over a 9-month period. They will also study the sources of microplastic exposure and the combined effects of microplastics and Helicobacter pylori. Participant involvement includes truthful completion of questionnaires and providing recent diagnostic results.
CONDITIONS
Brief Title
Association Between Microplastic Exposure and the Pathological Progression of Gastric Carcinogenesis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged between 18 and 75 years old, gender is not restricted
- Diagnosed within the last three months with chronic non-atrophic gastritis, precancerous lesions of gastric cancer, or gastric cancer for the first time
- Have clear Helicobacter pylori test results
- Are in a normal mental state and able to independently complete the questionnaire survey
You will not qualify if you...
- History of malignant tumors in other body parts
- Previous upper gastrointestinal surgery, chemotherapy, or radiotherapy
- Severe diseases affecting major organs such as heart, lungs, liver, or kidneys
- Currently receiving psychological treatment or taking psychiatric medications
- Pregnant or lactating women
- Severe missing clinical data or questionnaire information
- Refusal to sign the informed consent form
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 3 months
Participants undergo endoscopic and/or histopathological assessments to categorize their gastric mucosal condition.
1 to 2 visits depending on diagnostic procedures
Duration - 9 months
Participants are observed to assess microplastic exposure and related pathological stages of gastric mucosal carcinogenesis.
Periodic assessments during the 9-month observation period
Trial Site Locations
Total: 1 location
1
Xijing Hosipital of Digestive Disease
Xi'an, Shaanxi, China, 710032
Actively Recruiting
Research Team
Y
Yongquan Shi
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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