Study of Metformin Use Before Surgery and Its Effect on Nausea and Vomiting After General Anesthesia

What this Trial Is About

Researchers are investigating whether taking metformin before surgery affects the chances or severity of nausea and vomiting after surgery in patients who undergo general anesthesia with endotracheal intubation. This observational cohort study compares patients already prescribed metformin with those not taking the medication, aiming to understand its influence on postoperative nausea and vomiting PONV and recovery quality. The study is conducted at the Sixth Affiliated Hospital of Sun Yat-sen University and enrolls a total of 909 participants. Participants are divided into two groups those exposed to metformin before surgery and those not exposed. The primary focus is on the occurrence of PONV within 0 to 120 hours after surgery. Secondary aspects include measuring PONV incidence and severity at different time intervals, antiemetic medication use, and quality of recovery using the QoR-15 score assessed before surgery and at multiple points up to 120 hours post-surgery. During the study, patients will complete structured surveys assessing nausea and vomiting after their surgery. Researchers will collect data on recovery quality and medication use. The main outcome measured is the incidence of PONV during the first five days after surgery. The study began in December 2025 and will continue until December 2033, with participants monitored closely during the postoperative period for a detailed understanding of recovery outcomes and side effects.

Association Between Preoperative Metformin Exposure and Postoperative Nausea and Vomiting in Patients Undergoing General Anesthesia