Actively Recruiting
Association Between Renal Regional Oxygen Saturation Measured by Near-InfraRed Spectroscopy and Postoperative Renal Failure After Lung Transplantation Surgery: A Pilot Study
Led by Assistance Publique Hopitaux De Marseille · Updated on 2026-02-23
80
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the relationship between kidney oxygen levels during lung transplant surgery and the risk of kidney failure shortly after the operation. This observational study focuses on acute kidney injury, which affects more than half of lung transplant patients and sometimes requires kidney support treatments. The study aims to see if near-infrared spectroscopy (NIRS), a non-invasive method measuring kidney tissue oxygen, can predict early postoperative kidney failure by monitoring kidney hypoxia during surgery. Participants undergoing lung transplantation will have their kidney oxygen saturation measured using NIRS throughout the surgery. This technique has been used in heart surgeries but not extensively studied in lung transplants. The researchers will calculate a renal hypoxia index combining the depth and duration of low kidney oxygen levels during the operation to evaluate its predictive value for kidney failure. During the study, patients will be monitored closely for kidney function and complications for five days after surgery. Outcomes such as early acute kidney failure, use of kidney support therapies, survival status, changes in kidney function tests, and lung graft health will be recorded. This monitoring will help determine if intraoperative kidney oxygen monitoring can guide prevention strategies and improve outcomes after lung transplantation.
CONDITIONS
Brief Title
Association Between Renal Regional Oxygen Saturation Measured by Near-InfraRed Spectroscopy and Postoperative Renal Failure After Lung Transplantation Surgery: A Pilot Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient undergoing a lung transplant (single or double transplantation)
- Age 18 years or older
- Affiliated to the French social security system
You will not qualify if you...
- Renal anatomical abnormality likely to induce a misleading NIRS signal such as single kidney or polycystic kidney disease
- Expression of opposition to participation in the research protocol
- Hyperbilirubinemia greater than 17 mmol/l
- Preoperative extracorporeal membrane oxygenation (ECMO)
- Preoperative mechanical ventilation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 days post-surgery
Participants undergo lung transplantation surgery and immediate post-operative monitoring, including measurement of renal regional oxygen saturation using Near-InfraRed Spectroscopy.
Daily assessments during hospital stay up to 5 days
Duration - Up to 5 days post-surgery
Participants are monitored for early postoperative acute renal failure and other renal function outcomes after lung transplantation surgery.
Daily follow-up visits for up to 5 days
Trial Site Locations
Total: 1 location
1
Service d'anesthésie et réanimation adulte
Marseille, France
Actively Recruiting
Research Team
P
Pierre Mora
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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