Study of Physical Activity and Sedentary Lifestyle Patterns and Their Link to New Health Problems in Chronic Diseases Over 4 Years

What this Trial Is About

Researchers are investigating how physical activity and sedentary behavior relate to the development of additional chronic diseases and complications in patients with long-term health conditions. This study aims to identify a specific activity pattern or digital signature that could predict new health issues before they appear. The focus is on patients with various chronic diseases including inflammatory rheumatic diseases, osteoarthritis, major depressive and bipolar disorders, type 2 diabetes, obesity, COPD, and chronic pain. The study involves 700 patients followed over 4 years in a monocentric prospective cohort design. Participants will wear accelerometers three times a year for 5 days to precisely measure their movements and sedentary time. Annual visits will collect clinical data, assess physical capacity through tests like the 6-minute walk and hand grip, and involve questionnaires about pain, fatigue, anxiety, depression, quality of life, and other factors. Additional disease-specific data will also be gathered. Throughout the study, researchers will monitor the occurrence of new comorbidities yearly, correlating these with the recorded physical activity patterns. Electronic patient-reported outcomes will be collected every 4 months to assess health status, lifestyle, and psychological well-being. The main outcomes include identifying the digital signature of activity and sedentary lifestyle linked to new comorbidities after 4 years. Safety and ongoing health status will be regularly evaluated during the follow-up period.

Association of a Digital Signature of Physical Activity and Sedentary Lifestyle With the Development of Multimorbidities in Chronic Diseases (eMOB)