Association of Dysbiosis and Immune Response in Bronchiolitis in Infants Under 12 Months

What this Trial Is About

Researchers are studying acute bronchiolitis, a common lung infection in children under two years old caused mainly by the respiratory syncytial virus (RSV). The study aims to understand why it is difficult to predict how severe the infection will become by looking at the role of the microbiota (gut, oral, and nasal bacteria) and the immune response to RSV in affected children. This observational study includes infants under 12 months old with bronchiolitis during the RSV season. The study involves collecting samples from 80 infants with different severities of bronchiolitis, including hospitalized, non-hospitalized, and those in intensive care. Researchers will take oral, nasal, and stool samples to study the microbiota and will collect capillary or venous blood samples to analyze immune responses. These samples help identify bacterial imbalances and immune markers during infection. Participants will provide these samples once during their illness. Researchers will measure dysbiosis, immune system markers like cytokines and chemokines, viral genetics, RSV antibodies, and bacterial load. The study team monitors these factors to better understand infection severity and immune response. The study runs from December 2024 through April 2026, and participation involves only sample collection with no treatment interventions.

Association of Dysbiosis and Immune Response in Bronchiolitis in Under 12 Months -Old Infants