Actively Recruiting
Association of Dysbiosis and Immune Response in Bronchiolitis in Under 12 Months -Old Infants
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-02-26
120
Participants Needed
3
Research Sites
68 weeks
Total Duration
On this page
Sponsors
A
Assistance Publique - Hôpitaux de Paris
Lead Sponsor
I
Infectious Diseases Models for Innovative Therapies center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Acute bronchiolitis is a common disease in children under the age of two, caused mainly by the respiratory syncytial virus (RSV). Furthermore, given the same medical history, it is still very difficult to predict the course and severity of the infection at the onset of symptoms, Some studies have highlighted the importance of the microbiota (intestinal, oral or nasopharyngeal) and of the immune response to RSV in children, We will include 80 children under 2 years old with hospitalized bronchiolitis and non-hospitalized bronchiolitis. Oral, nasal and stool samples will be taken to study the various microbiota in search of dysbiosis. A capillary blood sample will be taken for immune studies.
CONDITIONS
Official Title
Association of Dysbiosis and Immune Response in Bronchiolitis in Under 12 Months -Old Infants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Infants younger than 12 months
- Bronchiolitis during RSV epidemic season
- No chronic illness
- No previous history of bronchiolitis
- Signed consent from parents or legal guardians
You will not qualify if you...
- Chronic respiratory illness
- History of bronchiolitis or newborn asthma
- Treatment with immunosuppressants
- No social security affiliation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
APHP, Antoine Béclère Hospital
Clamart, France, 92140
Actively Recruiting
2
AP-HP,Raymond Poincaré Hospital
Garches, France, 92380
Actively Recruiting
3
Réanimation médico-chirurgicale Necker
Paris, France, 750
Actively Recruiting
Research Team
E
Etienne BIZOT, Doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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