Actively Recruiting
Association of Gene Polymorphism With Susceptibility to T2DM and the Therapeutic Responses to Exenatide in Chinese Patients With T2DM
Led by The Affiliated Hospital of Xuzhou Medical University · Updated on 2025-09-18
300
Participants Needed
1
Research Sites
213 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a retrospective cohort study of patients with T2DM who were treated with exenatide twice daily as a part of their diabetes care for at least 12 months. The objective of this study is to investigate the influence of T2DM susceptibility gene polymorphisms (NOS1AP, KCNQ1, TCF7L2, WSF1, GLP-1R, etc.) on the efficacy of GLP-1 RA (exenatide, liraglutide, etc.), to identify the variables that can predict the efficacy of GLP-1 RA, and to evaluate the weight of these variables on the efficacy.
CONDITIONS
Official Title
Association of Gene Polymorphism With Susceptibility to T2DM and the Therapeutic Responses to Exenatide in Chinese Patients With T2DM
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of type 2 diabetes mellitus (T2DM)
- Body mass index (BMI) between 20 and 35 kg/m2
- HbA1c between 7.0% and 12%
- Age between 25 and 70 years
- Availability of required data at baseline and 6 months after GLP-1 RA therapy
You will not qualify if you...
- Serious diseases such as acute myocardial infarction, stroke, trauma, kidney or liver diseases, severe gastrointestinal dysfunction, or history of pancreatitis
- Use of GLP-1 analogues, weight loss drugs, glucocorticoids, or drugs affecting gastrointestinal peristalsis within the past 3 months
- Missing data at baseline, 3 months, or 6 months after GLP-1 RA therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
China, Jiangsu, Department of Endocrinology
Xuzhou, China, China, 221006
Actively Recruiting
Research Team
T
Tao Wang, Ph.D
CONTACT
X
Xiaoxing Yin, Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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