Actively Recruiting
The Association of Gut Microbiota and Spermatogenic Dysfunction
Led by Zhujiang Hospital · Updated on 2024-07-24
306
Participants Needed
3
Research Sites
123 weeks
Total Duration
On this page
Sponsors
Z
Zhujiang Hospital
Lead Sponsor
N
National Natural Science Foundation of China
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a multicenter, case-control study that aims to investigate the relationship between microbiota and sperm quality via stool, blood, and urine microbiome, metabolomics, and collected clinical metadata. The results of the spermatogenic dysfunction, including aspermia, oligozoospermia, asthenozoospermia, and teratozoospermia, will be compared to normal basic semen analysis utilizing the World Health Organization (WHO) semen analysis procedure 5th edition.
CONDITIONS
Official Title
The Association of Gut Microbiota and Spermatogenic Dysfunction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male aged 18 to 45 years
- Body Mass Index (BMI) between 18.5 and 29.9 kg/m²
- Two abnormal semen analyses after 2 to 7 days of abstinence
- Azoospermia group: absence of spermatozoa in both semen samples
- Oligozoospermia group: total sperm number less than 39 million per ejaculate or sperm concentration less than 15 million per ml
- Asthenozoospermia group: progressive motility less than 32%
- Teratozoospermia group: morphologically normal sperm less than 4%
- Willingness to provide feces, urine, and blood samples
- Ability to complete study questionnaires on lifestyle factors and other data collection tools
You will not qualify if you...
- Age under 18 or over 45 years
- Use of Zocanidin, Vitamin E, antibiotics, clyster, gastrointestinal endoscope, or other semen/gut microbiota affecting drugs in past 30 days
- High alcohol intake recently or weekly drinking in past month
- Known genetic causes of male spermatogenic dysfunction such as chromosomal or gene disorders
- History of male reproductive system damage, surgery, tumor, or infection
- History of Crohn's disease, ulcerative colitis, acute gastrointestinal disease, renal failure, liver cirrhosis, hypoplasia, X-rays exposure, or related spermatogenic dysfunction diseases
- History of intestinal or gastrointestinal surgery (except appendix surgery)
- History of psychoses or mental conditions causing cognitive impairment preventing study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Guangdong Provincial Fertility Hospital
Guangzhou, Guangdong, China, 510000
Not Yet Recruiting
2
Guangdong Second Provincial General Hospital
Guangzhou, Guangdong, China, 510000
Not Yet Recruiting
3
Zhujiang Hospital of Southern Medical University
Guanzhou, Guangdong, China, 510280
Actively Recruiting
Research Team
S
Shuo Wang
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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