Study of Pregnancy History and Circulating Biomarkers in Women Aged 60-74 With Heart Failure and Preserved Ejection Fraction

What this Trial Is About

Researchers are studying women aged 60 to 74 years who have heart failure with preserved ejection fraction HFpEF and a history of pregnancy lasting at least 20 weeks. The study aims to investigate how various circulating biomarkers and pregnancy-related factors like gestational hypertension, preeclampsia, gestational diabetes, preterm delivery, stillbirth, and miscarriage relate to the prognosis of HFpEF. These pregnancy factors are considered as potential risks for cardiovascular disease. Participants undergo an initial visit where they complete a questionnaire about pregnancy complications, menopause, and medical history. Medical records provide additional data on comorbidities and test results. Physical exams measure body data and signs of heart congestion, and surveys assess breath shortness severity. Blood samples are collected to measure specific biomarkers linked to heart failure, such as high-sensitivity troponin I and cystatin C. Echocardiography is performed to evaluate heart muscle function. Twelve months after the first visit, researchers follow up by phone to collect information about new chronic diseases, emergency hospitalizations, major heart-related events, or death. If participants cannot be reached, trusted contacts are called to determine their status. The main outcome measured is a combined endpoint of emergency hospital admission, major cardiovascular events, or death within one year. This observational study tracks health status and heart failure progression over time.

Association of Heterogeneous Circulating Biomarkers and Anamnestic Factors of Pregnancy Adverse Course and Outcomes With the Prognosis of Heart Failure With Preserved Ejection Fraction