Actively Recruiting
Inflammation Study in Pregnant Women With and Without Intrahepatic Cholestasis of Pregnancy
Led by University Hospital, Brest · Updated on 2024-10-16
322
Participants Needed
11
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
This research aims to understand whether an immune process similar to allograft rejection causes intrahepatic cholestasis of pregnancy ICP. The study includes pregnant women with and without ICP to explore if immunomodulatory treatments might be helpful. It is an observational study conducted by the University Hospital, Brest, focused on inflammation in ICP. The study involves 322 pregnant women at delivery, divided into two groups 161 women diagnosed with ICP and 161 without ICP. Blood tests will be performed on both mothers and newborns to measure various biological markers related to inflammation, allograft rejection, and angiogenesis. Placental tissue will also be analyzed to check for chronic inflammation. Participants will provide blood samples and placenta at delivery for detailed analysis. Researchers will compare biological and placental markers between the ICP and non-ICP groups. The main outcome measured is the prevalence of placental chronic inflammation at delivery, alongside levels of biological factors involved in inflammation, rejection, and angiogenesis. The study will monitor these outcomes at delivery and conclude by June 2025.
CONDITIONS
Brief Title
Association of Intrahepatic Cholestasis of Pregnancy and Chronic Placental Inflammation
Research Team
C
Claire de Moreuil
P
Philippe Merviel
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