Actively Recruiting
Association of Intraoperative Blood Pressure Excursions Below Cerebral Autoregulatory Boundaries With Organ Injury Following Major Noncardiac Surgery
Led by University Hospital, Basel, Switzerland · Updated on 2025-07-17
650
Participants Needed
3
Research Sites
241 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of study is to investigate the clinical relevance of blood pressure (BP) excursions below cerebral autoregulatory boundaries in major noncardiac surgery. The study seeks to establish a precedent for a personalized definition of intraoperative arterial hypotension based on non-invasive tissue oxygenation measurements. The feasibility of NIRS-based autoregulation monitoring in major noncardiac surgery and the prognostic relevance of BP excursions below the NIRS-derived lower limit of autoregulation (LLA) with regard to major cardiovascular, renal and neurological complications will be investigated.
CONDITIONS
Official Title
Association of Intraoperative Blood Pressure Excursions Below Cerebral Autoregulatory Boundaries With Organ Injury Following Major Noncardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Undergoing major noncardiac surgery under general anesthesia, including vascular surgery (except arteriovenous shunt, vein stripping, carotid endarterectomies), intraperitoneal, intrathoracic, or major orthopedic surgery
- At cardiovascular risk by meeting at least one of these: NT-proBNP ≥ 200 ng/l, history of coronary artery disease, peripheral vascular disease, stroke, major vascular surgery (except excluded types), or at least three of the following: major surgery type, history of heart failure or pulmonary edema, transient ischemic attack, diabetes treated with medication, age over 70 years, history of hypertension, serum creatinine > 175 mcmol/l or creatinine clearance < 60 l/min/1.73m2, smoking within 2 years
- Intraoperative continuous invasive blood pressure monitoring is planned
- Surgery planned for at least 90 minutes
- Planned postoperative hospital stay of at least one night
- For neurologic injury substudy: age 65 years or older
You will not qualify if you...
- Pregnant women
- Emergency surgery
- Urological surgery
- Severe kidney failure with creatinine clearance less than 30 ml/min or dialysis
- Participation in interventional trials with overlapping endpoints, except possible inclusion in colchicine trial subset
- Previously enrolled in this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
University Hospital Basel, Clinic for Anaesthesia, Intermediate Care, Prehospital Emergency Medicine and Pain Therapy
Basel, Switzerland, 4031
Actively Recruiting
2
Inselspital, Bern University Hospital, Department of Anaesthesiology and Pain Medicine
Bern, Switzerland, 3010
Actively Recruiting
3
Cantonal Hospital St. Gallen, Division of Perioperative Intensive Care Medicine
Sankt Gallen, Switzerland, 9007
Actively Recruiting
Research Team
P
Patrick M Wanner, Dr. med.
CONTACT
L
Luzius A Steiner, Prof. Dr. med.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here