Actively Recruiting
Association of Microcirculation, Vexus Score and Femoral Vein Doppler in Patients on the ICU After Non-emergency Cardiac Surgery
Led by University Hospital, Basel, Switzerland · Updated on 2026-04-20
40
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the relationship between venous congestion and microcirculatory impairment in patients who have undergone elective or urgent cardiac surgery and are staying in the intensive care unit (ICU) postoperatively. The study aims to understand whether ultrasound signs of venous congestion, detected by tools like the Vexus score and femoral vein Doppler, are linked to problems in the tiny blood vessels that deliver oxygen and nutrients to body tissues. This is important because current monitoring often focuses on larger blood flow measures, which may not reflect true tissue health. The study involves observing patients after non-emergency cardiac surgery using ultrasound-based assessments of venous congestion alongside advanced imaging of microcirculation under the tongue with handheld vital microscopy and automated software. Measurements will be taken at three time points: before surgery, on the first day after surgery, and six hours after that to compare differences in blood flow velocity and vessel density between patients with and without signs of venous congestion. Participants will undergo these assessments during their ICU stay, including ultrasound exams and microcirculation analysis. Researchers will monitor changes in small vessel blood flow and density, comparing results based on ultrasound indicators. The study will track these measures at specified time points to evaluate the link between venous congestion and microvascular function. The total participation duration depends on the timing of surgery and follow-up within the ICU period.
CONDITIONS
Brief Title
Association of Microcirculation, Vexus Score and Femoral Vein Doppler in Patients on the ICU After Non-emergency Cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �318 years
- Undergoing elective or urgent (non-emergency) cardiac surgery
You will not qualify if you...
- Younger than 18 years
- Pregnant women
- Severe chronic kidney disease (estimated glomerular filtration rate less than 15 mL/min per 1.73 m2) or dialysis
- History of kidney or liver transplantation
- Conditions interfering with portal system Doppler evaluation (e.g., cirrhosis, portal vein thrombosis, large abdominal emphysema)
- Unable to provide consent for the study
- Emergency cardiac surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From prior to surgery up to the first postoperative day plus 6 hours after
Participants undergo ultrasound assessments and microcirculation measurements before and after cardiac surgery to evaluate venous congestion and microvascular function.
3 assessments: prior to surgery, first postoperative day, and 6 hours after first postoperative day
Duration - Duration of ICU stay after surgery
Participants are observed in the ICU after non-emergency cardiac surgery to monitor microcirculatory function and venous congestion using ultrasound and vital microscopy.
Visits aligned with ICU stay as per routine care
Trial Site Locations
Total: 1 location
1
University Hospital Basel
Basel, Switzerland, 4031
Actively Recruiting
Research Team
G
Gregor Loosen,, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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