Actively Recruiting

Age: 18Years +
All Genders
ID07052461

Association of Microcirculation, Vexus Score and Femoral Vein Doppler in Patients on the ICU After Non-emergency Cardiac Surgery

Led by University Hospital, Basel, Switzerland · Updated on 2026-04-20

40

Participants Needed

1

Research Sites

52 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are investigating the relationship between venous congestion and microcirculatory impairment in patients who have undergone elective or urgent cardiac surgery and are staying in the intensive care unit (ICU) postoperatively. The study aims to understand whether ultrasound signs of venous congestion, detected by tools like the Vexus score and femoral vein Doppler, are linked to problems in the tiny blood vessels that deliver oxygen and nutrients to body tissues. This is important because current monitoring often focuses on larger blood flow measures, which may not reflect true tissue health. The study involves observing patients after non-emergency cardiac surgery using ultrasound-based assessments of venous congestion alongside advanced imaging of microcirculation under the tongue with handheld vital microscopy and automated software. Measurements will be taken at three time points: before surgery, on the first day after surgery, and six hours after that to compare differences in blood flow velocity and vessel density between patients with and without signs of venous congestion. Participants will undergo these assessments during their ICU stay, including ultrasound exams and microcirculation analysis. Researchers will monitor changes in small vessel blood flow and density, comparing results based on ultrasound indicators. The study will track these measures at specified time points to evaluate the link between venous congestion and microvascular function. The total participation duration depends on the timing of surgery and follow-up within the ICU period.

CONDITIONS

Brief Title

Association of Microcirculation, Vexus Score and Femoral Vein Doppler in Patients on the ICU After Non-emergency Cardiac Surgery

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age �318 years
  • Undergoing elective or urgent (non-emergency) cardiac surgery
Not Eligible

You will not qualify if you...

  • Younger than 18 years
  • Pregnant women
  • Severe chronic kidney disease (estimated glomerular filtration rate less than 15 mL/min per 1.73 m2) or dialysis
  • History of kidney or liver transplantation
  • Conditions interfering with portal system Doppler evaluation (e.g., cirrhosis, portal vein thrombosis, large abdominal emphysema)
  • Unable to provide consent for the study
  • Emergency cardiac surgery

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - From prior to surgery up to the first postoperative day plus 6 hours after

Participants undergo ultrasound assessments and microcirculation measurements before and after cardiac surgery to evaluate venous congestion and microvascular function.

3 assessments: prior to surgery, first postoperative day, and 6 hours after first postoperative day

Long-term Monitoring

Duration - Duration of ICU stay after surgery

Participants are observed in the ICU after non-emergency cardiac surgery to monitor microcirculatory function and venous congestion using ultrasound and vital microscopy.

Visits aligned with ICU stay as per routine care

Trial Site Locations

Total: 1 location

1

University Hospital Basel

Basel, Switzerland, 4031

Actively Recruiting

Loading map...

Research Team

G

Gregor Loosen,, MD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

Similar Trials

Effect of VExUS Ultrasound Protocol on Fluid Management and ...

Thoracic Surgery With One-lung Ventilation

Actively Recruiting

1 location

Evaluation of the Microcirculatory Response to Fluids in Cri...

Venous Congestion

Actively Recruiting

1 location

Frequently Asked Questions

Have more questions? Get in touch with our team for quick support

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here