Actively Recruiting
Association of Middle Molecules Clearance and Clinical Parameters With Haemodiafiltration Convection Volume
Led by East and North Hertfordshire NHS Trust · Updated on 2024-07-23
400
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
People with severe kidney failure often need treatments like dialysis or transplant to survive. This research investigates haemodiafiltration (HDF), a dialysis method that uses both diffusion and convection to remove toxins. Large clinical trials suggest that HDF with high convection volume may help patients live longer, but the exact reasons are unclear. The study aims to understand how HDF convection volume relates to clearing middle-sized toxins called Beta 2-Microglobulin and other clinical factors. This observational study will include 400 adults who have been receiving HDF for at least three months. Participants will be observed during one routine dialysis session where clinical data and dialysis information, including convection volume, will be recorded. Blood tests will be taken before and after dialysis to measure the removal of middle molecules and assess their relationship to convection volume. Throughout the study, researchers will collect data on blood pressure, body temperature, inflammation markers, and Beta 2-Microglobulin levels to explore how these relate to HDF convection volume. The main outcomes include the relationship between convection volume and Beta 2-Microglobulin reduction and pre-dialysis levels over 18 months. This study aims to improve dialysis prescriptions by focusing on middle molecule clearance and simplify kidney function estimation methods.
CONDITIONS
Brief Title
Association of Middle Molecules Clearance With HDF Volume
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or above
- Ability to give informed consent
- End stage renal failure treated by dialysis for at least 3 months
- Established on haemodiafiltration for more than 4 weeks
- Prognosis more than 6 months as assessed by the principal investigator
You will not qualify if you...
- Age less than 18 years
- Inability to give informed consent
- Prognosis less than 6 months as assessed by the principal investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single dialysis session
Participants who undergo routine haemodiafiltration treatment are observed during a single dialysis session to record clinical parameters and dialysis convection volume. Blood samples are taken before and after the session to measure middle molecule removal and other clinical markers.
1 study visit during routine dialysis
Trial Site Locations
Total: 1 location
1
East and North Hertfordshire NHS Trust
Stevenage, Hertfordshire, United Kingdom, SG1 4AB
Actively Recruiting
Research Team
U
Usama A Butt, MBBS,MRCP
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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