Studying How Gum Inflammation Affects Immune Response During Healing After Tooth Extraction in Adults Aged 21 to 70

What this Trial Is About

This research aims to understand how inflammation in the mouth affects the immune response during wound healing after tooth extraction. The study involves healthy adults aged 21 to 70 who need a posterior tooth extracted. Researchers will measure periodontal inflammation and take dental X-rays before the extraction to gather baseline information. Participants will undergo an atraumatic extraction of the affected tooth using local anesthesia. Small soft tissue biopsies from the extraction site will be collected immediately after extraction and again two weeks later when sutures are removed. A final visit at three months post-extraction will include clinical assessments and dental X-rays to evaluate healing. Throughout the study, researchers will collect data such as probing depths, gum recession, bleeding, and fluid samples from adjacent teeth. The soft tissue samples will be analyzed to count inflammatory cells and study immune activity during healing. Participants will be involved in three main visits over about three months, with careful monitoring of healing and inflammation.

Association of Periodontal Inflammation on Immune Response in Wound Healing