Actively Recruiting
Association of Periodontal Inflammation on Immune Response in Wound Healing after Posterior Tooth Extraction
Led by University of Nebraska · Updated on 2025-12-10
25
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand how inflammation in the mouth affects the immune response during wound healing after tooth extraction. The study involves healthy adults aged 21 to 70 who need a posterior tooth extracted. Researchers will measure periodontal inflammation and take dental X-rays before the extraction to gather baseline information. Participants will undergo an atraumatic extraction of the affected tooth using local anesthesia. Small soft tissue biopsies from the extraction site will be collected immediately after extraction and again two weeks later when sutures are removed. A final visit at three months post-extraction will include clinical assessments and dental X-rays to evaluate healing. Throughout the study, researchers will collect data such as probing depths, gum recession, bleeding, and fluid samples from adjacent teeth. The soft tissue samples will be analyzed to count inflammatory cells and study immune activity during healing. Participants will be involved in three main visits over about three months, with careful monitoring of healing and inflammation.
CONDITIONS
Brief Title
Association of Periodontal Inflammation on Immune Response in Wound Healing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult aged 21 to 70 years
- Have a non-restorable posterior tooth (molar or premolar) needing extraction
You will not qualify if you...
- Presence of systemic disease that affects inflammation and wound healing processes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 day
Participants undergo extraction of a posterior tooth with local anesthesia, followed by a soft tissue biopsy and suturing of the extraction site.
1 visit (in-person)
Duration - 2 weeks
Participants return at two weeks for suture removal and a second soft tissue biopsy, along with clinical assessments of the healing site and adjacent teeth.
1 visit (in-person)
Duration - 3 months
At three months post-extraction, participants have clinical evaluations of wound healing, including inflammatory measures and radiographic imaging of the adjacent teeth and extraction site.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
University of Nebraska, College of Dentistry
Lincoln, Nebraska, United States, 68583
Actively Recruiting
Research Team
A
Amy C Killeen, DDS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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