Actively Recruiting
Association of TNFAIP3 With Immune-mediated TTP
Led by Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Updated on 2026-03-27
400
Participants Needed
1
Research Sites
51 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to investigate whether genetic variation in the TNFAIP3 locus is associated with immune-mediated thrombotic thrombocytopenic purpura (iTTP), and whether such association is mediated by decreased expression of A20 (TNFAIP3). The study includes a case-control design to assess genotype-expression association and a cohort study to evaluate clinical outcomes such as disease relapse.
CONDITIONS
Official Title
Association of TNFAIP3 With Immune-mediated TTP
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of immune-mediated thrombotic thrombocytopenic purpura (iTTP)
- Age 12 years or older
- Caucasian ethnicity and Italian origin
- Provided written informed consent to participate in the study
You will not qualify if you...
- Does not meet all the inclusion criteria listed above
AI-Screening
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Trial Site Locations
Total: 1 location
1
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Milan, Italy, 20122
Actively Recruiting
Research Team
I
Ilaria Mancini, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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