Actively Recruiting
Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults
Led by Universidade Federal do Rio de Janeiro · Updated on 2024-12-13
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
Universidade Federal do Rio de Janeiro
Lead Sponsor
A
Alzheimer's Association
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are exploring new ways to help older adults with cognitive decline, including those with Mild Cognitive Impairment and early Alzheimer's Disease. This study evaluates the combined use of Digital Cognitive Training (DCT) and Transcranial Alternating Current Stimulation (tACS) to see if this approach is feasible, safe, and may improve cognitive function. The study also investigates how these interventions affect brain activity and blood biomarkers related to cognitive health. Participants receive five daily sessions where they use the BrainHQ platform for 30 minutes of cognitive exercises while simultaneously undergoing tACS targeting the left dorsolateral prefrontal cortex. One group receives active stimulation at 6Hz and 1.6mA, while the comparison group receives sham (placebo-like) stimulation with no current during the session. This design aims to compare the effects of real versus sham brain stimulation combined with cognitive training. During the study, participants undergo assessments including the Montreal Cognitive Assessment (MoCA) one week after the intervention to measure cognitive changes. Additional tests evaluate attention, memory, verbal fluency, and brain activity using event-related potentials and eye tracking. Blood samples are collected before treatment to analyze proteins linked to cognitive decline. The study carefully monitors safety and tolerability throughout, with participation lasting about one week post-intervention for follow-up evaluations.
CONDITIONS
Brief Title
Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy subjects over 50 years old
- Presence of cognitive complaints
You will not qualify if you...
- Estimated Intelligence Quotient less than 80
- Dependence on psychoactive substances (DSM-V)
- Severe psychiatric or neurological disorders
- Uncorrected visual or hearing problems
- History of unexplained syncope or seizure within the past year
- Previous stroke
- Use of anticoagulants
- Presence of intracranial metallic prosthesis or cardiac pacemaker
- Any contraindication to performing transcranial alternating current stimulation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 5 consecutive days
Participants receive 5 daily sessions of 30 minutes of digital cognitive training using the BrainHQ platform combined with either active or sham transcranial alternating current stimulation targeting the left dorsolateral prefrontal cortex.
5 daily visits (in-person)
Duration - 1 week after intervention
Participants undergo assessments of cognitive function, neurophysiological measures, and serum biomarkers to evaluate the effects of the intervention.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Clínica da Memória - IPUB / UFRJ
Rio de Janeiro, Rio de Janeiro, Brazil, 22290140
Actively Recruiting
Research Team
R
Rogerio Panizzutti, Professor
B
Brunno Costa, PhD student
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here