Using BrainHQ Digital Cognitive Training Combined with Transcranial Alternating Current Stimulation to Improve Cognitive Function in Adults Over 50 with Memory Concerns

What this Trial Is About

Researchers are exploring new ways to help older adults with cognitive decline, including those with Mild Cognitive Impairment and early Alzheimers Disease. This study evaluates the combined use of Digital Cognitive Training DCT and Transcranial Alternating Current Stimulation tACS to see if this approach is feasible, safe, and may improve cognitive function. The study also investigates how these interventions affect brain activity and blood biomarkers related to cognitive health. Participants receive five daily sessions where they use the BrainHQ platform for 30 minutes of cognitive exercises while simultaneously undergoing tACS targeting the left dorsolateral prefrontal cortex. One group receives active stimulation at 6Hz and 1.6mA, while the comparison group receives sham placebo-like stimulation with no current during the session. This design aims to compare the effects of real versus sham brain stimulation combined with cognitive training. During the study, participants undergo assessments including the Montreal Cognitive Assessment MoCA one week after the intervention to measure cognitive changes. Additional tests evaluate attention, memory, verbal fluency, and brain activity using event-related potentials and eye tracking. Blood samples are collected before treatment to analyze proteins linked to cognitive decline. The study carefully monitors safety and tolerability throughout, with participation lasting about one week post-intervention for follow-up evaluations.

Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults