Study of Ultrasound Signs of Adenomyosis in the Uterus and Their Link to Symptoms in Pre- and Perimenopausal Women

What this Trial Is About

This research aims to explore the connection between ultrasound features of the myometrium suggestive of adenomyosis and the clinical symptoms experienced by women. Adenomyosis is a condition where endometrial tissue grows within the muscular wall of the uterus, often causing pain, abnormal bleeding, and fertility issues. The study focuses on pre- and perimenopausal women, both with and without symptoms, to better understand the severity of the disease and improve diagnosis using ultrasound imaging according to MUSA criteria. Participants will undergo a routine gynecological ultrasound exam during a single visit, with no interventions or treatments given as part of the study. They will complete a questionnaire about their symptoms and bleeding patterns. The study will analyze the ultrasound features such as asymmetrical thickening, cysts, and shadowing in relation to pain and bleeding severity. The goal is also to develop an ultrasound-based grading system that combines imaging features with symptom severity. During the study visit, participants will have their ultrasound data collected and complete standardized assessments of pain and bleeding. The clinical and ultrasound information will be documented in electronic records and reviewed by the study team. Researchers will measure the association between ultrasound signs and symptom severity at the time of the exam. The study plans to enroll about 1000 women over three years across multiple centers, including 400 in Switzerland, with the primary evaluation occurring during one visit without follow-up treatments or procedures.

Association of Ultrasound Features of the Myometrium Suggestive of Adenomyosis and Clinical Symptoms