Actively Recruiting
The Association of Urinary BDNF and NGF With Lower Urinary System Parameters in Patients With Bladder Outlet Obstruction Secondary to Benign Prostate Hyperplasia
Led by Marmara University · Updated on 2025-08-22
70
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Benign Prostatic Hyperplasia (BPH) is a common condition in older men characterized by enlargement of the prostate, leading to lower urinary tract symptoms (LUTS) such as frequent urination, urgency, nocturia, difficulty urinating, and feeling of incomplete bladder emptying. This study investigates the levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in urine samples to understand their role in bladder outlet obstruction caused by BPH and the related changes in the bladder. Researchers aim to compare these levels before and after surgical procedures to relieve obstruction, as well as with control patients without obstruction.
CONDITIONS
Brief Title
Association of Urine BDNF and NGF With Lower Urinary System Parameters
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male aged 50 to 80 years
- Diagnosed with bladder outlet obstruction due to benign prostate hyperplasia
You will not qualify if you...
- Known neurological disease
- Diabetes
- Urinary tract infection
- Previous prostate surgery
- Spinal cord trauma
- Bladder stone
- Cerebrovascular disease
- Chronic renal failure
- Ureteral stenosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 month before surgery
Participants diagnosed with bladder outlet obstruction due to benign prostate hyperplasia provide urine samples and undergo baseline evaluations before surgery.
1 to 2 visits before surgery
Duration - Surgery day and immediate recovery period
Participants undergo holmium laser enucleation of the prostate to remove obstruction.
1 day of surgery with post-operative assessments
Duration - Up to 1 year
Participants are monitored after surgery with urine sample collection and uroflowmetry to assess changes in lower urinary system parameters.
Periodic visits during 1 year follow-up
Duration - Study duration up to 1 year
Participants without lower urinary tract disease provide urine samples for comparison.
1 to 2 visits during the study
Trial Site Locations
Total: 1 location
1
Marmara University Hospital
Istanbul, Turkey (Türkiye)
Actively Recruiting
Research Team
H
Haydar Kamil ÇAM, Prof. Dr.
K
Kader Ada Doğan, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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