Testing Astaxanthin Supplement for Managing Mild-to-Moderate Asthma in Adults Living in Polluted Areas

What this Trial Is About

Researchers are evaluating whether astaxanthin, a natural antioxidant supplement, can improve lung function, reduce airway inflammation, and enhance asthma control in adults with mild-to-moderate asthma. The study also examines the influence of indoor and personal air pollution on asthma symptoms, airway responsiveness, and treatment response. Exploratory thoracic bioelectrical impedance spectroscopy alongside standard respiratory tests will be assessed. Participants receive astaxanthin 12 mg daily orally as three 4 mg capsules taken with their largest meal or matched placebo capsules in a double-blind, randomized crossover design. Each treatment period lasts 4 weeks, separated by a 3-week washout between treatments. Participants follow one of two sequences astaxanthin then placebo, or placebo then astaxanthin. During the study, researchers will perform lung function tests including spirometry, impulse oscillometry, body plethysmography, and hypertonic saline challenges with induced sputum collection. Participants will monitor peak expiratory flow at home and complete questionnaires about asthma control and quality of life. Indoor and personal air pollution exposure will be tracked throughout. The primary outcomes measured include changes in lung function, exhaled nitric oxide, and airway responsiveness after each treatment period.

Can Astaxanthin Help Manage Asthma in POlluted Areas?