POStoperative INTELLiVENT-adaptive Support VEntilation in Cardiac Surgery Patients II (POSITiVE II) - a Randomized Clinical Trial

What this Trial Is About

Researchers are evaluating the use of INTELLiVENT-ASV, an automated ventilation mode, compared to conventional ventilation in patients receiving postoperative ventilation after cardiac surgery. The study aims to assess the quality of ventilation, the workload on ICU nursing staff, and clinical outcomes such as the duration of postoperative ventilation and length of ICU stay. This international, randomized clinical trial includes adult patients undergoing elective cardiac surgery. Participants will be randomly assigned to receive either INTELLiVENT-ASV, which automatically adjusts ventilation settings based on patient needs, or conventional ventilation where clinicians set and monitor parameters like tidal volume and respiratory rate. The study focuses on the early postoperative period, particularly the first two hours of ICU ventilation, with monitoring continuing through the duration of mechanical ventilation and ICU stay. During the trial, patients will undergo continuous monitoring of ventilation quality, nursing workload, and clinical outcomes including ventilation duration and length of stay in ICU and hospital. Additional assessments include patient-ventilator synchrony and mortality within 28 days. The study involves detailed data collection during ICU admission and ventilation, with follow-up up to 30 days after admission to evaluate hospital outcomes.

I-ASV in Cardiac Surgery