Actively Recruiting
ATENEA Study: Adherence to Creatine-Based Nutritional Supplementation in Estrogen-Depleted Women
Led by Margan Biotech · Updated on 2026-05-12
100
Participants Needed
4
Research Sites
27 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective, multicenter, observational clinical study conducted under routine clinical practice conditions aimed at describing adherence to a creatine-based nutritional supplement (Creaticare FEM) in estrogen-depleted adult women. Participants will receive the supplement for 12 weeks, and adherence will be assessed as the percentage of doses consumed and the proportion of participants achieving ≥80% adherence. Secondary outcomes include persistence, satisfaction, tolerability, and adherence to recommended physical activity. Exploratory outcomes include changes in muscle strength, body composition, quality of life, joint pain, and skin health.
CONDITIONS
Official Title
ATENEA Study: Adherence to Creatine-Based Nutritional Supplementation in Estrogen-Depleted Women
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Biological female sex
- Age 40 years or older
- Estrogen-depleted status defined by one of the following: natural menopause with at least 12 consecutive months of amenorrhea; surgically induced menopause; or late perimenopause with elevated FSH as judged clinically
- No major health problems that would prevent use of the supplement or recommended physical activity
- No significant changes in usual treatment within the previous 3 months
- Ability to understand study information and provide written consent
- Willingness to take the nutritional supplement as instructed
- Willingness to follow general physical activity recommendations
- Ability and willingness to attend scheduled visits and complete assessments through 12 weeks
You will not qualify if you...
- Started or changed treatment with GLP-1 receptor agonists within the past 12 weeks
- Musculoskeletal or joint conditions severely limiting regular physical activity or study assessments
- Clinically relevant kidney or liver disease
- Current use of diuretics or medications potentially harmful to the kidneys
- Known allergy or intolerance to any ingredient of the supplement
- Participation in another nutritional, pharmacological, or interventional clinical study within the past 3 months
- Any medical or social condition judged by the investigator to interfere with study participation, adherence, or data validity
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 4 locations
1
Clínica Palacios
Madrid, Madrid, Spain, 28034
Actively Recruiting
2
Menoclinica by Palacios
Madrid, Madrid, Spain, 28034
Actively Recruiting
3
Ginegetafe
Madrid, Madrid, Spain, 28901
Actively Recruiting
4
Clinica Palacios Málaga
Málaga, Málaga, Spain, 29016
Not Yet Recruiting
Research Team
S
Silvia Martinez
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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