Actively Recruiting
Atezolizumab-bevacizumab and Other Immunotherapies: Real-life Experience for Treatment of Hepatocellular Carcinoma
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2025-02-04
1000
Participants Needed
24
Research Sites
462 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
\- Background Hepatocellular carcinoma (HCC), is the fifth most common cancer worldwide and the third leading cause of cancer-related death. In most cases (about 80%), HCC develops in a cirrhotic liver - a condition where the liver has been damaged over time, leading to scarring. This makes treatment more challenging. This study will gather and analyze data from patients treated in real-world settings to: 1. Understand the effectiveness and safety of new treatment combinations (e.g., atezolizumab-bevacizumab and durvalumab-tremelimumab). Identify the best treatment sequences for patients with advanced liver cancer. 2. Discover clinical and laboratory markers that predict treatment responses, helping personalize care and optimize outcomes. By addressing these questions, this study will provide valuable information to healthcare providers and guide future treatment decisions for patients with liver cancer.
CONDITIONS
Official Title
Atezolizumab-bevacizumab and Other Immunotherapies: Real-life Experience for Treatment of Hepatocellular Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hepatocellular carcinoma not amenable to locoregional procedures
- Candidate to frontline systemic treatment with atezolizumab-bevacizumab or other immunotherapies
You will not qualify if you...
- Concurrent treatment with other antineoplastic agents
- Other active neoplasia
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 24 locations
1
Ospedali Riuniti Ancona, Via Conca, 71, 60126 Torrette AN
Torrette, AN, Italy, 60126
Actively Recruiting
2
I.R.C.C.S. "S. De Bellis", Via Turi, 27, 70013 Castellana Grotte BA
Castellana Grotte, BA, Italy, 70013
Not Yet Recruiting
3
AUSL Bologna Via Castiglione 15 40136 Bologna BO
Bologna, BO, Italy, 40136
Actively Recruiting
4
IRCCS Azienda Ospedaliero-Universitaria di Bologna (Oncology Unit), Bologna, BO 40136
Bologna, BO, Italy, 40136
Actively Recruiting
5
IRCCS Azienda Ospedaliero-Universitaria di Bologna (Semiotics Unit)
Bologna, BO, Italy, 40136
Actively Recruiting
6
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, BO, Italy, 40136
Actively Recruiting
7
Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione "Garibaldi, Piazza Santa Maria di Gesù, 5, 95123 Catania CT
Catania, CT, Italy, 95123
Not Yet Recruiting
8
Ospedali Riuniti. Viale Pinto Luigi, 1, 71122 Foggia FG.
Foggia, FG, Italy, 71122
Actively Recruiting
9
Ospedali Riuniti. Viale Pinto Luigi, 1, 71122 Foggia FG
Foggia, FG, Italy, 71122
Not Yet Recruiting
10
AOU Careggi. Largo G. Alessandro Brambilla, 3. 50134 Firenze FI
Florence, FI, Italy, 50134
Actively Recruiting
11
Policlinico di Modena Via del Pozzo, 71, 41125 Modena MO
Modena, Missouri, Italy, 41125
Not Yet Recruiting
12
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico. via Francesco Sforza, 28 - 20122 Milano.
Milan, MI, Italy, 20122
Actively Recruiting
13
ASST Grande Ospedale Metropolitano Niguarda, Piazza dell'Ospedale Maggiore, 3, 20162 Milano
Milan, MI, Italy, 20162
Not Yet Recruiting
14
Humanitas Research Hospital. Via Alessandro Manzoni, 56, 20089 Rozzano MI
Rozzano, MI, Italy, 20089
Actively Recruiting
15
Azienda Ospedaliero- Universitaria Paolo Giaccone. Via Liborio Giuffrè, 5, 90127 Palermo
Palermo, PA, Italy, 90127
Actively Recruiting
16
Istituto Oncologico Veneto. Via Gattamelata, 64, 35128 Padova PD
Padova, PD, Italy, 35128
Actively Recruiting
17
AOU Pisana. Via Roma 67. 56126 Pisa PI
Pisa, PI, Italy, 56126
Actively Recruiting
18
Ospedale degli Infermi Viale Stradone, 9 48018 Faenza (RA)
Faenza, RA, Italy, 48018
Actively Recruiting
19
IRCCS Santa Maria Nuova Viale Risorgimento, 80, 42123 Reggio Emilia
Reggio Emilia, RE, Italy, 42123
Not Yet Recruiting
20
Policlinico Gemelli. Largo Agostino Gemelli, 8, 00168 Roma RM
Roma, RM, Italy, 00168
Actively Recruiting
21
Azienda sanitaria universitaria Friuli Centrale, Piazzale Santa Maria della Misericordia, 15 33100 Udine (UD)
Udine, UD, Italy, 33100
Not Yet Recruiting
22
Azienda Ospedaliera Universitaria Integrata di Verona. Piazzale Aristide Stefani, 1, 37126 Verona VR
Verona, VR, Italy, 37126
Actively Recruiting
23
P.O. Ospedale del Mare. Via Enrico Russo, 11, 80147 Napoli NA
Naples, Italy, 80147
Actively Recruiting
24
Azienda Ospedaliero- Universitaria Maggiore della Carità, Padiglione G, L.go Bellini, 28100 Novara NO
Novara, Italy, 28100
Not Yet Recruiting
Research Team
F
Francesco Tovoli, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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