Actively Recruiting

Age: 18Years - 80Years
All Genders
ID07388108

Atrial Electromechanical Alteration as a Predictor of Arrhythmias in the Postoperative Period After Cardiovascular Surgery

Led by School of Medicine. National University of Cuyo · Updated on 2026-02-10

138

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying whether non-invasive echocardiographic techniques can better predict the risk of developing arrhythmias, specifically atrial fibrillation, after cardiovascular surgery. The study focuses on detecting inter- and intra-atrial dyssynchrony as a key factor that might increase this risk. It aims to describe atrial deformation patterns and evaluate new methods like left atrial ejection fraction via 3D echocardiography in predicting postoperative atrial fibrillation. Before surgery, patients will receive a detailed Doppler echocardiogram using atrial strain analysis with speckle tracking to measure atrial activation timing and deformation across multiple left and right atrial segments. This includes a novel approach called "OMEGA" to assess simultaneous atrial contractions. These measurements help identify atrial dyssynchrony. Patients will then be monitored during hospitalization and followed up by phone at 28 and 365 days after surgery. Participants will have continuous heart rhythm monitoring for five days post-surgery to detect atrial fibrillation. Follow-up interviews at 28 and 365 days will check for supraventricular arrhythmias. Data are collected electronically for analysis. The main outcome is the occurrence of atrial fibrillation from surgery until hospital discharge, with secondary outcomes measured at 28 and 365 days. This study plans to enroll 138 patients and track them through their hospital stay and one year afterward for arrhythmia events.

CONDITIONS

Brief Title

Atrial Dyssynchrony to Predict Arrhythmias in the Postoperative Setting of Cardiovascular Surgery.

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients scheduled for non-mitral cardiovascular surgery
  • Patients in sinus rhythm (normal heart rhythm)
  • Patients who have given informed consent to participate
  • Adults aged 18 to 80 years
  • No atrial fibrillation upon hospital admission for surgery
Not Eligible

You will not qualify if you...

  • Surgery involving the mitral or tricuspid valve
  • History of previous atrial fibrillation
  • History of congenital heart disease or cardiac tumors
  • Emergency heart surgery
  • Poor echocardiographic imaging window

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Day of surgery

Participants undergo echocardiographic assessments including atrial strain analysis to evaluate atrial dyssynchrony before cardiovascular surgery.

1 visit (in-person)

Monitoring

Duration - Up to 5 days

Participants are continuously monitored via electrocardiography during hospitalization for up to 5 days post-surgery to detect atrial fibrillation.

Continuous monitoring during hospital stay

Surveillance

Duration - 365 days

Participants receive telephonic follow-up interviews to assess for arrhythmias at 28 days and 365 days after surgery.

2 phone calls (at 28 and 365 days post-surgery)

Trial Site Locations

Total: 1 location

1

Clínica de Cuyo

Mendoza, Mendozz, Argentina, 5500

Actively Recruiting

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Research Team

F

Francisco Sánchez, PhD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Published Research Related To This Trial

Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients.

Francisco J Sánchez, Valeria A Gonzalez, Martin Farrando...

https://pubmed.ncbi.nlm.nih.gov/33456678

Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging.

Luigi P Badano, Theodore J Kolias, Denisa Muraru...

https://pubmed.ncbi.nlm.nih.gov/29596561

The role of the right atrium in development of postoperative atrial fibrillation: A speckle tracking echocardiography study.

Uğur Aksu, Kamuran Kalkan, Oktay Gulcu...

https://pubmed.ncbi.nlm.nih.gov/31099024

Correlation between total atrial conduction time estimated via tissue Doppler imaging (PA-TDI Interval), structural atrial remodeling and new-onset of atrial fibrillation after cardiac surgery.

Patrick Müller, Christine Hars, Fabian Schiedat...

https://pubmed.ncbi.nlm.nih.gov/23398627

Atrial activation time determined by transthoracic Doppler tissue imaging can be used as an estimate of the total duration of atrial electrical activation.

Klaartje L Merckx, Cees B De Vos, Andrea Palmans...

https://pubmed.ncbi.nlm.nih.gov/16153518

Intra-Atrial Dyssynchrony During Sinus Rhythm Predicts Recurrence After the First Catheter Ablation for Atrial Fibrillation.

Luisa Ciuffo, Susumu Tao, Esra Gucuk Ipek...

https://pubmed.ncbi.nlm.nih.gov/29361492

Elevated pre-operative serum peptides for collagen I and III synthesis result in post-surgical atrial fibrillation.

Michael F Swartz, Gregory W Fink, Muhammad F Sarwar...

https://pubmed.ncbi.nlm.nih.gov/23040566

Interatrial block and atrial remodeling assessed using speckle tracking echocardiography.

Juan Lacalzada-Almeida, María Manuela Izquierdo-Gómez, Carima Belleyo-Belkasem...

https://pubmed.ncbi.nlm.nih.gov/29466939