Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients.
Francisco J Sánchez, Valeria A Gonzalez, Martin Farrando...
https://pubmed.ncbi.nlm.nih.gov/33456678Actively Recruiting
Led by School of Medicine. National University of Cuyo · Updated on 2026-02-10
138
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are studying whether non-invasive echocardiographic techniques can better predict the risk of developing arrhythmias, specifically atrial fibrillation, after cardiovascular surgery. The study focuses on detecting inter- and intra-atrial dyssynchrony as a key factor that might increase this risk. It aims to describe atrial deformation patterns and evaluate new methods like left atrial ejection fraction via 3D echocardiography in predicting postoperative atrial fibrillation. Before surgery, patients will receive a detailed Doppler echocardiogram using atrial strain analysis with speckle tracking to measure atrial activation timing and deformation across multiple left and right atrial segments. This includes a novel approach called "OMEGA" to assess simultaneous atrial contractions. These measurements help identify atrial dyssynchrony. Patients will then be monitored during hospitalization and followed up by phone at 28 and 365 days after surgery. Participants will have continuous heart rhythm monitoring for five days post-surgery to detect atrial fibrillation. Follow-up interviews at 28 and 365 days will check for supraventricular arrhythmias. Data are collected electronically for analysis. The main outcome is the occurrence of atrial fibrillation from surgery until hospital discharge, with secondary outcomes measured at 28 and 365 days. This study plans to enroll 138 patients and track them through their hospital stay and one year afterward for arrhythmia events.
CONDITIONS
Atrial Dyssynchrony to Predict Arrhythmias in the Postoperative Setting of Cardiovascular Surgery.
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery
Participants undergo echocardiographic assessments including atrial strain analysis to evaluate atrial dyssynchrony before cardiovascular surgery.
1 visit (in-person)
Duration - Up to 5 days
Participants are continuously monitored via electrocardiography during hospitalization for up to 5 days post-surgery to detect atrial fibrillation.
Continuous monitoring during hospital stay
Duration - 365 days
Participants receive telephonic follow-up interviews to assess for arrhythmias at 28 days and 365 days after surgery.
2 phone calls (at 28 and 365 days post-surgery)
Total: 1 location
1
Clínica de Cuyo
Mendoza, Mendozz, Argentina, 5500
Actively Recruiting
F
Francisco Sánchez, PhD
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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