Actively Recruiting

Age: 18Years +
All Genders
ID04696081

Multicenter International Prospective Registry to Identify Major Cardiovascular Events Associated With the Occurrence of Atrial Fibrillation in Active Cancer Patients

Led by University Hospital, Caen · Updated on 2024-08-09

1000

Participants Needed

1

Research Sites

17 weeks

Total Duration

On this page

Sponsors

U

University Hospital, Caen

Lead Sponsor

U

University Hospital, Marseille, France

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are studying atrial fibrillation, a common heart rhythm problem, in adults who have active cancer. This study aims to better understand the occurrence and consequences of major cardiovascular events in these patients, which are not well covered by current cancer and heart disease guidelines. The study is an international, multicenter, prospective registry focusing on adults with cancer and atrial fibrillation. Adult patients with active cancer who experience atrial fibrillation are included in this observational study. Active cancer is defined as cancer diagnosed within the past 6 months, recurrent locally advanced or metastatic cancer, or patients receiving anticancer treatment currently or within 6 months before enrollment. Both new onset and recurring atrial fibrillation after cancer diagnosis are considered. Patients are followed for 1 year to track cardiovascular events and death. Participants will be monitored for major cardiovascular events and overall survival for one year from inclusion in the registry. Researchers will describe the patient population, atrial fibrillation management, and identify risk factors associated with cardiovascular events, mortality, and bleeding during this period. The study involves collecting patient information without changing their usual care, allowing close observation of the health outcomes related to atrial fibrillation in cancer patients.

CONDITIONS

Brief Title

Atrial Fibrillation in Active Cancer Patients

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adult patients
  • Outpatients or hospitalized patients
  • Confirmed active cancer diagnosed within the past 6 months or recurrent locally advanced or metastatic cancer
  • At least one episode of atrial fibrillation after cancer diagnosis
  • In sinus rhythm at the time of cancer diagnosis
Not Eligible

You will not qualify if you...

  • Patients receiving palliative care or expected to die within one month following atrial fibrillation occurrence
  • History of long-standing persistent or permanent atrial fibrillation prior to cancer diagnosis

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surveillance

Duration - 1 year

Participants who have active cancer and atrial fibrillation are observed to identify major cardiovascular events and other health outcomes.

Periodic assessments over 1 year

Trial Site Locations

Total: 1 location

1

Alexandre

Caen, Normandy, France, 14000

Actively Recruiting

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Research Team

J

Joachim Alexandre, MD, PhD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Published Research Related To This Trial

Identification of anticancer drugs associated with atrial fibrillation: analysis of the WHO pharmacovigilance database.

Joachim Alexandre, Joe-Elie Salem, Javid Moslehi...

https://pubmed.ncbi.nlm.nih.gov/32353110