Actively Recruiting

Phase Not Applicable
Age: 70Years +
All Genders
NCT05134454

Atrial Fibrillation Screening Post Ischemic Cerebrovascular Events

Led by Karolinska Institutet · Updated on 2024-10-10

3300

Participants Needed

1

Research Sites

305 weeks

Total Duration

On this page

Sponsors

K

Karolinska Institutet

Lead Sponsor

U

Uppsala University

Collaborating Sponsor

AI-Summary

What this Trial Is About

Stroke is one of the leading causes behind death and permanent disability in adults. Atrial fibrillation (AF) is the most common clinical arrhythmia and its prevalence is steeply increasing with age. Atrial fibrillation is associated with a manifold increase in the risk for stroke. It is considered important to investigate the heart rhythm in stroke survivors without previously known AF, because detection of AF will prompt a change in antithrombotic treatment with subsequent lowering of the risk of recurrent stroke. There are so far very few studies on the prognostic impact of ECG investigations post stroke. Despite this knowledge gap, ECG investigation post stroke is given high priority in national and international guidelines. Considerable clinical resources are currently invested in these ECG investigations without knowledge of its utility. The investigators plan a nationwide, randomised, register-based study (RRCT) including patients aged at least 70 years receiving in-hospital care for stroke or TIA (Transient Ischemic Attack). Included patients will be randomised to standard investigation (1-2 days of ECG ) or extended ECG investigation (14 days of ECG performed at least twice). Patients diagnosed AF will be offered anticoagulation treatment. Long-term follow-up will be performed via swedish health care registers. The result of this trial will have major impact on the ECG screening recommendations for patients who have had stroke, a large group of patients with dismal prognosis.

CONDITIONS

Official Title

Atrial Fibrillation Screening Post Ischemic Cerebrovascular Events

Who Can Participate

Age: 70Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients aged 70 years or older
  • Diagnosis of ischemic stroke or transient ischemic attack (TIA) within 14 days before inclusion
Not Eligible

You will not qualify if you...

  • Previously diagnosed atrial fibrillation
  • Contraindications to oral anticoagulant treatment
  • Need for anticoagulant treatment for reasons other than atrial fibrillation (such as venous thromboembolism or mechanical heart valve)
  • Use of dual antiplatelet therapy that cannot be switched to oral anticoagulation
  • Presence of a pacemaker, implantable cardioverter defibrillator, or implantable cardiac monitor
  • Inability to comply with the study protocol as judged by the investigator

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

Karolinska Institutet Danderyds University Hospital

Stockholm, Sweden, 18288

Actively Recruiting

Loading map...

Research Team

J

Johan Engdahl, MD, PhD

CONTACT

K

Kajsa Strååt, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

DIAGNOSTIC

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here

Atrial Fibrillation Screening Post Ischemic Cerebrovascular Events | DecenTrialz