Actively Recruiting
Atrial Fibrillation Screening Post Ischemic Cerebrovascular Events
Led by Karolinska Institutet · Updated on 2024-10-10
3300
Participants Needed
1
Research Sites
305 weeks
Total Duration
On this page
Sponsors
K
Karolinska Institutet
Lead Sponsor
U
Uppsala University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Stroke is one of the leading causes behind death and permanent disability in adults. Atrial fibrillation (AF) is the most common clinical arrhythmia and its prevalence is steeply increasing with age. Atrial fibrillation is associated with a manifold increase in the risk for stroke. It is considered important to investigate the heart rhythm in stroke survivors without previously known AF, because detection of AF will prompt a change in antithrombotic treatment with subsequent lowering of the risk of recurrent stroke. There are so far very few studies on the prognostic impact of ECG investigations post stroke. Despite this knowledge gap, ECG investigation post stroke is given high priority in national and international guidelines. Considerable clinical resources are currently invested in these ECG investigations without knowledge of its utility. The investigators plan a nationwide, randomised, register-based study (RRCT) including patients aged at least 70 years receiving in-hospital care for stroke or TIA (Transient Ischemic Attack). Included patients will be randomised to standard investigation (1-2 days of ECG ) or extended ECG investigation (14 days of ECG performed at least twice). Patients diagnosed AF will be offered anticoagulation treatment. Long-term follow-up will be performed via swedish health care registers. The result of this trial will have major impact on the ECG screening recommendations for patients who have had stroke, a large group of patients with dismal prognosis.
CONDITIONS
Official Title
Atrial Fibrillation Screening Post Ischemic Cerebrovascular Events
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 70 years or older
- Diagnosis of ischemic stroke or transient ischemic attack (TIA) within 14 days before inclusion
You will not qualify if you...
- Previously diagnosed atrial fibrillation
- Contraindications to oral anticoagulant treatment
- Need for anticoagulant treatment for reasons other than atrial fibrillation (such as venous thromboembolism or mechanical heart valve)
- Use of dual antiplatelet therapy that cannot be switched to oral anticoagulation
- Presence of a pacemaker, implantable cardioverter defibrillator, or implantable cardiac monitor
- Inability to comply with the study protocol as judged by the investigator
AI-Screening
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Trial Site Locations
Total: 1 location
1
Karolinska Institutet Danderyds University Hospital
Stockholm, Sweden, 18288
Actively Recruiting
Research Team
J
Johan Engdahl, MD, PhD
CONTACT
K
Kajsa Strååt, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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