Atrial arrhythmias in adults with congenital heart disease.
Judith Bouchardy, Judith Therrien, Louise Pilote...
https://pubmed.ncbi.nlm.nih.gov/19822808Actively Recruiting
Age: 13Years +
All Genders
ID05241418
Atrial Late Gadolinium Enhancement in Patients with Repaired Congenital Heart Disease
Led by Boston Children's Hospital · Updated on 2025-02-13
50
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research focuses on patients aged 13 and older with congenital heart disease who have undergone surgical repair and may develop atrial arrhythmias such as intra-atrial reentrant tachycardia and atrial fibrillation. The study aims to better understand how well scar tissue in the heart's atria can be seen using cardiac MRI with a contrast agent called gadolinium. Researchers want to learn how these MRI findings relate to measurements taken during procedures in the electrophysiology laboratory. Participants will have cardiac MRI scans as part of their usual medical care, involving the use of gadolinium contrast to visualize scar tissue in the heart's atria. The study will analyze 3D late gadolinium enhancement images to quantify atrial fibrosis and compare these findings with voltage maps obtained during electrophysiology procedures. This imaging technique is being evaluated for its reproducibility and potential to provide insight into heart tissue changes in patients with repaired congenital heart disease. During the study, participants will undergo cardiac MRI scans and may have electrophysiology laboratory evaluations as part of their routine care. Researchers will measure total atrial fibrosis using 3D late gadolinium enhancement MRI over one year and compare it with voltage mapping results over two years. They will also track occurrences of sustained atrial arrhythmias lasting more than 30 seconds over five years using ECG and monitoring methods. The study is observational and focuses on collecting detailed imaging and clinical data to better understand heart scarring in this population.
CONDITIONS
Brief Title
Atrial Late Gadolinium Enhancement in Patients with Repaired Congenital Heart Disease
Who Can Participate
Age: 13Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Patients older than 13 years with congenital heart disease
- Referred for cardiac MRI and receiving gadolinium contrast as part of routine clinical care or for pre-ablation planning
You will not qualify if you...
- Self-reported anxiety or claustrophobia
- Presence of a permanent pacemaker or implantable cardioverter defibrillator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration - 1 day
Participants undergo a cardiac MRI with gadolinium contrast to take pictures of the atria and identify scar tissue.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 5 years
Participants are observed over several years to assess atrial fibrosis and monitor for sustained atrial arrhythmias.
Trial Site Locations
Total: 1 location
1
Boston Children's Hospital
Boston, Massachusetts, United States, 02130
Actively Recruiting
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Research Team
D
Daniel A Castellanos, MD
E
Edward O'Leary, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
Increasing Prevalence of Atrial Fibrillation and Permanent Atrial Arrhythmias in Congenital Heart Disease.
Fabien Labombarda, Robert Hamilton, Azadeh Shohoudi...
https://pubmed.ncbi.nlm.nih.gov/28797355Association of atrial fibrosis quantified using LGE-MRI with atrial appendage thrombus and spontaneous contrast on transesophageal echocardiography in patients with atrial fibrillation.
Nazem Akoum, Genaro Fernandez, Brent Wilson...
https://pubmed.ncbi.nlm.nih.gov/23844972Association of atrial tissue fibrosis identified by delayed enhancement MRI and atrial fibrillation catheter ablation: the DECAAF study.
Nassir F Marrouche, David Wilber, Gerhard Hindricks...
https://pubmed.ncbi.nlm.nih.gov/24496537Atrial Fibrosis by Late Gadolinium Enhancement Magnetic Resonance Imaging and Catheter Ablation of Atrial Fibrillation: 5-Year Follow-Up Data.
Mihail G Chelu, Jordan B King, Eugene G Kholmovski...
https://pubmed.ncbi.nlm.nih.gov/30511895Left Atrial Fibrosis and Risk of Cerebrovascular and Cardiovascular Events in Patients With Atrial Fibrillation.
Jordan B King, Peyman N Azadani, Promporn Suksaranjit...
https://pubmed.ncbi.nlm.nih.gov/28882227Optimization of late gadolinium enhancement cardiovascular magnetic resonance imaging of post-ablation atrial scar: a cross-over study.
Henry Chubb, Shadman Aziz, Rashed Karim...
https://pubmed.ncbi.nlm.nih.gov/29720202Substrate characterization of the right ventricle in repaired tetralogy of Fallot using late enhancement cardiac magnetic resonance.
Nuria Rivas-Gándara, Laura Dos-Subirá, Jaume Francisco-Pascual...
https://pubmed.ncbi.nlm.nih.gov/34098087Three-Dimensional Late Gadolinium Enhancement Cardiovascular Magnetic Resonance Predicts Inducibility of Ventricular Tachycardia in Adults With Repaired Tetralogy of Fallot.
Sarah Ghonim, Sabine Ernst, Jenny Keegan...
https://pubmed.ncbi.nlm.nih.gov/33022183