Actively Recruiting
Attentional Biases, Reward Sensitivity, and Cognitive Control in Adults With Bipolar Disorder
Led by University Hospitals Cleveland Medical Center · Updated on 2025-10-10
100
Participants Needed
1
Research Sites
387 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to use eye-tracking technology to study attentional biases, reward sensitivity, and cognitive control in adult patients with bipolar disorder with or without anxiety and/or substance use disorder comorbidity.
CONDITIONS
Official Title
Attentional Biases, Reward Sensitivity, and Cognitive Control in Adults With Bipolar Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female, age 18 or older
- Meets diagnostic criteria for lifetime bipolar I or II disorder as confirmed by Mini International Neuropsychiatric Interview (MINI)
- Currently in a depressive episode or remission from a mood episode (for groups 1-4)
- Young Mania Rating Scale total score ≤ 8 (for groups 1-4)
- Hamilton Anxiety Rating Scale total score ≥ 18 for groups with current anxiety disorder
- Meets diagnostic criteria for current anxiety disorder for groups 2 and 3
- Meets diagnostic criteria for substance use disorder within last 3 months for groups 3 and 4
- Capable of understanding and complying with protocol requirements
- Competent to understand and sign informed consent
- Compliant with taking psychiatric medications as per investigator's discretion (for groups 1-4)
- Physically healthy and without any current or lifetime psychiatric disorder for healthy volunteers (group 5)
You will not qualify if you...
- Significant structural brain lesion (e.g., infarct, hemorrhage, tumor, multiple sclerosis)
- Progressive neurological disease such as neurodegenerative disease
- Current psychiatric disorder not allowed for specific groups, including OCD, PTSD, ADHD, antisocial personality disorder, and borderline personality disorder
- Currently pregnant or planning to become pregnant
- Tests positive for illegal substances or prescription medications without valid prescription
- Currently taking steroids, stimulants, or opioid painkillers
- Meets DSM-5 criteria for alcohol or drug use disorder within last 6 months (with exceptions)
- Currently experiencing nicotine use disorder or used nicotine products within one week before study
- Had electroconvulsive therapy (ECT) treatment within the last 6 months
- Intoxicated or in acute withdrawal state (for groups with substance use disorders)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospitals Cleveland Medical Center - Mood Disorders Program
Cleveland, Ohio, United States, 44106
Actively Recruiting
Research Team
N
Nicole Jones
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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