Actively Recruiting
Attentional Mechanisms in SCD
Led by Vanderbilt University Medical Center · Updated on 2025-06-24
80
Participants Needed
1
Research Sites
170 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will use an anticholinergic pharmacological probe to examine attention network function in SCD using EEG. The overall hypothesis is that in older adults with SCD, normal cognitive performance is maintained by compensatory attention network activity, supported by enhanced cholinergic function. The investigators anticipate that SCD will be associated with greater compensatory attention network activity and that disrupting this compensatory process through anticholinergic challenge will result in a greater negative effect on attentional performance (Attention Network Test, ANT) and attention network functioning (EEG) in older adults with greater subjective cognitive concern.
CONDITIONS
Official Title
Attentional Mechanisms in SCD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 55 years or older
- Montreal Cognitive Assessment (MoCA) score greater than 25
- Global Deterioration Scale (GDS) rating less than 3
- Non-smokers
You will not qualify if you...
- Medical contraindications to the drug challenge
- Primary neurological disorder such as stroke or epilepsy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212
Actively Recruiting
Research Team
K
Kimberly Albert, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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