Actively Recruiting
Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)
Led by Indiana University · Updated on 2025-12-17
300
Participants Needed
2
Research Sites
241 weeks
Total Duration
On this page
Sponsors
I
Indiana University
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors), which will test the efficacy of an internet CBT intervention called Good Days Ahead (GDA) to reduce the burden of subjective cognitive decline (SCD) in older ICU survivors with moderate to severe depressive symptoms after ICU hospitalization.
CONDITIONS
Official Title
Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 50 years of age and older
- Admitted to intensive care for more than 48 hours
- Able to understand and provide informed consent
- Elevated depressive symptoms defined by PHQ-9 or PHQ-8 scores (≥10, or 5-9 with core symptoms of anhedonia or depressed mood)
- Willing to participate in cognitive testing
- Access to a telephone
- Discharged to home or an independent or assisted living facility
- Evidence of subjective cognitive decline, memory change in past 1-3 years, or low score on Montreal Cognitive Assessment adjusted for demographics
You will not qualify if you...
- Diagnosis of dementia or neurodegenerative disease before ICU stay or on anti-dementia medications
- Diagnosis of severe mental illness such as bipolar disorder, schizophrenia, or schizoaffective disorder
- Persistent psychotic symptoms after ICU stay
- Recent or recurrent alcohol or substance use disorder
- Life expectancy less than 1 year (e.g., terminal cancer, hospice care)
- History of ischemic or hemorrhagic stroke, traumatic brain injury, or neurosurgery around ICU stay
- Uncorrected vision or hearing impairments including legal blindness or deafness
- Status post tracheostomy and unable to communicate
- Currently incarcerated or on parole after ICU stay
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Eskenazi Hospital
Indianapolis, Indiana, United States, 46202
Actively Recruiting
2
IU Health Methodist Hospital
Indianapolis, Indiana, United States, 46202
Actively Recruiting
Research Team
B
Babar Khan, MD, MS
CONTACT
L
Lori Rawlings, RN, BSN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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