Study of Hearing and Balance Function in Children and Young Adults Aged 12 to 20 with Osteogenesis Imperfecta

What this Trial Is About

Researchers are investigating whether vestibular problems occur in people aged 12 to 20 with Osteogenesis Imperfecta OI, a genetic bone disorder also linked to hearing loss. They aim to find if theres a relationship between the type and severity of OI and specific hearing and balance issues. The study involves detailed hearing and balance tests to better understand these connections and to explore bone changes seen on imaging scans. Participants will undergo several hearing tests including audiometry and immittance assessments, along with vestibular evaluations such as videonystagmography, video Head Impulse Test, and vestibular evoked muscular potentials. If hearing loss or vestibular deficits are found, patients will have a CT scan of the ear bones. Those with sensorineural hearing loss or abnormal CT results will be offered an MRI to further assess inner ear and nerve structures. During the study, participants will complete these tests as part of their annual medical visit, with results tracked over 24 months. Researchers will measure various vestibular functions and hearing abilities, as well as assess the severity of OI and bone changes on imaging. This comprehensive evaluation aims to clarify the connection between OI and balance or hearing problems while monitoring patients health over two years.

Audio-vestibular Evaluation of Children and Young Adults With Osteogenesis Imperfecta