Study of Surgery and Heated Chemotherapy for Treating Abdominal Cancers Monitoring Heart, Blood Pressure, and Body Temperature Changes Around Surgery

What this Trial Is About

Peritoneal carcinomatosis often occurs in colorectal and digestive tract cancers. Researchers are auditing perioperative changes in patients undergoing cytoreductive surgery CRS combined with hyperthermic intraperitoneal chemotherapy HIPEC, focusing on the challenges and physiological changes during this complex treatment. This observational study aims to better understand the effects and management of these procedures in patients treated for cancers such as colorectal, gastric, ovarian, or peritoneal mesothelioma. The treatment involves CRS to remove visible metastatic disease in the abdomen and pelvis, along with HIPEC where heated chemotherapy is applied inside the abdomen for 90 minutes at 42C. This extensive procedure can lead to significant blood and fluid loss, as well as cardiovascular and metabolic changes before, during, and after surgery. The study collects perioperative data from patients receiving this combined treatment to monitor these effects. Participants will be monitored from the start of surgery up to 48 hours afterward to track changes in blood pressure, body temperature, cardiac output, and arterial blood gases. Secondary measures include length of stay in intensive care and mortality up to 30 days post-surgery. The study aims to document perioperative physiological alterations and related outcomes to improve coordinated care by the surgical and anesthetic teams.

An Audit of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy