Actively Recruiting
Led by Tata Memorial Centre · Updated on 2024-11-21
400
Participants Needed
1
Research Sites
4 weeks
Total Duration
Peritoneal carcinomatosis often occurs in colorectal and digestive tract cancers. Researchers are auditing perioperative changes in patients undergoing cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC), focusing on the challenges and physiological changes during this complex treatment. This observational study aims to better understand the effects and management of these procedures in patients treated for cancers such as colorectal, gastric, ovarian, or peritoneal mesothelioma. The treatment involves CRS to remove visible metastatic disease in the abdomen and pelvis, along with HIPEC where heated chemotherapy is applied inside the abdomen for 90 minutes at 42ºC. This extensive procedure can lead to significant blood and fluid loss, as well as cardiovascular and metabolic changes before, during, and after surgery. The study collects perioperative data from patients receiving this combined treatment to monitor these effects. Participants will be monitored from the start of surgery up to 48 hours afterward to track changes in blood pressure, body temperature, cardiac output, and arterial blood gases. Secondary measures include length of stay in intensive care and mortality up to 30 days post-surgery. The study aims to document perioperative physiological alterations and related outcomes to improve coordinated care by the surgical and anesthetic teams.
CONDITIONS
An Audit of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From start of surgery up to 48 hours after surgery
Participants undergo cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and are monitored closely during the perioperative period.
Continuous monitoring during hospital stay
Duration - Up to 30 days after surgery
Participants are observed for recovery including length of stay in intensive care and survival for up to 30 days after surgery.
Approximately 1 to 2 follow-up visits
Total: 1 location
1
Tata Memorial Hospital
Mumbai, Maharashtra, India, 400012
Actively Recruiting
S
Sohan L Solanki, MD
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Sohan Lal Solanki, Vandana Agarwal, Reshma P Ambulkar...
https://pubmed.ncbi.nlm.nih.gov/39760061