Actively Recruiting
AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction
Led by Aurion Biotech · Updated on 2026-04-08
120
Participants Needed
12
Research Sites
97 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to assess the efficacy and safety of single injection dose of AURN001 compared with placebo in adult participants with corneal edema secondary to corneal endothelial dysfunction.
CONDITIONS
Official Title
AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have corneal edema secondary to corneal endothelial dysfunction requiring surgery (full- or partial-thickness endothelial keratoplasty)
- Best Corrected Visual Acuity (BCVA) between 65 ETDRS letters (about 20/50) and 5 ETDRS letters (about 20/800)
- Be pseudophakic with posterior chamber intraocular lens (PCIOL)
You will not qualify if you...
- Have progressive corneal dystrophies or degenerations
- Have visually significant corneal or other ocular pathologies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 12 locations
1
Investigational Site 2
Mesa, Arizona, United States, 85206
Actively Recruiting
2
Investigational Site 6
Little Rock, Arkansas, United States, 72205
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3
Investigational Site 9
Fort Collins, Colorado, United States, 80528
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4
Investigational Site 7
Atlanta, Georgia, United States, 30339
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5
Investigational Site 4
Kansas City, Missouri, United States, 64154
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6
Investigational Site 11
Leland, North Carolina, United States, 28451
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7
Investigational Site 5
Winston-Salem, North Carolina, United States, 27157
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8
Investigational Site 3
Cynwyd, Pennsylvania, United States, 19004
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9
Investigational Site 10
Plymouth Meeting, Pennsylvania, United States, 19462
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10
Investigational Site 12
Ladson, South Carolina, United States, 29456
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11
Investigational Site 8
San Antonio, Texas, United States, 78209
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12
Investigational Site 1
Spring, Texas, United States, 77388
Actively Recruiting
Research Team
A
Aurion Study Team
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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