Actively Recruiting
AusCADASIL: An Australian Cohort of CADASIL
Led by Perminder Sachdev · Updated on 2024-05-08
300
Participants Needed
5
Research Sites
174 weeks
Total Duration
On this page
Sponsors
P
Perminder Sachdev
Lead Sponsor
P
Prince of Wales Hospital, Sydney
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this project is to establish an Australian cohort of patients diagnosed with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). This study will examine the clinical features and longitudinal course of CADASIL. Outcome measures include neuropsychological profile, neuroimaging, genetics, blood biomarkers, and retinal imaging.
CONDITIONS
Official Title
AusCADASIL: An Australian Cohort of CADASIL
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years old or older
- Ability to provide written informed consent, with large-print and easy-to-read versions available for support
- Ability to attend a testing site
- Ability to complete medical examination, medical history questionnaire, blood test, and short neuropsychology assessment
- CADASIL participants meeting one of: confirmed genetic diagnosis (NOTCH3 variant), suspected diagnosis based on history and MRI, or first-degree relative of confirmed case
- Unrelated individuals negative for NOTCH3 variant with no cognitive complaints (control participants)
You will not qualify if you...
- Significant cognitive impairment that prevents providing informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
John Hunter Hospital
Newcastle, New South Wales, Australia, 2305
Actively Recruiting
2
Prince of Wales Hospital
Sydney, New South Wales, Australia, 2031
Actively Recruiting
3
University of New South Wales
Sydney, New South Wales, Australia, 2031
Actively Recruiting
4
Royal Brisbane and Women's Hospital
Brisbane, Queensland, Australia, 4006
Not Yet Recruiting
5
Royal Melbourne Hospital
Melbourne, Victoria, Australia, 3052
Actively Recruiting
Research Team
D
Danit Saks, MBMSc, MRes, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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