Actively Recruiting
AusCADASIL: An Australian Cohort of CADASIL to Study Clinical Features and Progression
Led by Perminder Sachdev · Updated on 2024-05-08
300
Participants Needed
5
Research Sites
N/A
Total Duration
On this page
Sponsors
P
Perminder Sachdev
Lead Sponsor
P
Prince of Wales Hospital, Sydney
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are establishing an Australian group of patients diagnosed with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). The study aims to understand the clinical features and how CADASIL progresses over time. It focuses on examining neuropsychological profiles, brain imaging, genetics, blood markers, and retinal imaging to gather comprehensive information about this condition. This observational study is conducted at multiple centers across Australia, including clinics, hospitals, and universities. Participants undergo clinical exams, questionnaires, neuropsychological tests, brain MRI scans, blood sample collection, and retinal imaging. The study includes both individuals with CADASIL and control participants without the genetic variant or cognitive complaints. Participants will complete assessments at the start and annually over four years, including medical questionnaires, cognitive tests, brain scans, blood tests, and eye exams. These evaluations measure cognitive function, physical health, brain changes, and quality of life. Researchers will monitor participants’ progress over time to better understand CADASIL and its impact.
CONDITIONS
Brief Title
AusCADASIL: An Australian Cohort of CADASIL
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older
- Ability to provide written informed consent, with support options available for visual or cognitive impairments
- Ability to attend a testing site for assessments
- Ability to complete medical examination, history questionnaire, blood test for genetic status, and a short neuropsychology assessment
- Diagnosed with CADASIL confirmed by genetic testing, suspected by medical history and MRI, or first-degree relative of someone with confirmed CADASIL
- Control participants must be unrelated individuals negative for the CADASIL genetic variant and without cognitive complaints
You will not qualify if you...
- Significant cognitive impairment that prevents providing informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Baseline assessments
Participants undergo clinical examinations, questionnaires, neuropsychological evaluations, blood sampling, retinal imaging, and brain MRI scans to characterize clinical features of CADASIL.
1 baseline visit (in-person)
Duration - Up to 4 years
Participants complete annual online questionnaires and clinical assessments to monitor disease progression over several years.
Annual visits at Year 1, Year 2, Year 3, and Year 4 (in-person or online depending on assessment)
Trial Site Locations
Total: 5 locations
1
John Hunter Hospital
Newcastle, New South Wales, Australia, 2305
Actively Recruiting
2
Prince of Wales Hospital
Sydney, New South Wales, Australia, 2031
Actively Recruiting
3
University of New South Wales
Sydney, New South Wales, Australia, 2031
Actively Recruiting
4
Royal Brisbane and Women's Hospital
Brisbane, Queensland, Australia, 4006
Not Yet Recruiting
5
Royal Melbourne Hospital
Melbourne, Victoria, Australia, 3052
Actively Recruiting
Research Team
D
Danit Saks, MBMSc, MRes, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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