Observational Study on Endoscopic Resection Techniques for Upper Gastrointestinal Cancers in Australia and New Zealand

What this Trial Is About

Researchers are collecting long-term data on patients undergoing different endoscopic proceduresEndoscopic Submucosal Dissection ESD, Endoscopic Full Thickness Resection EFTR, and Submucosal-Tunnelling Endoscopic Resection STERto treat upper gastrointestinal UGI neoplastic lesions. The study aims to evaluate lesion characteristics, procedural outcomes, safety, and effectiveness in removing these lesions. It is an observational study sponsored by the Western Sydney Local Health District. Patients referred for resection of gastrointestinal neoplasms will undergo one of the endoscopic procedures ESD, EFTR, or STER. Observational data will be collected on the lesions histology, the completeness of resection, safety events such as bleeding or perforation, and long-term outcomes including recurrence or residual disease. The study will monitor outcomes at various time points ranging from 1 day to 3 years after the procedures. Participants will be monitored through clinical assessments, patient interviews, questionnaires, and procedural data collection. Primary outcomes include the completeness of lesion resection within 2 weeks, safety within 30 days, and long-term disease status over 3 years. Secondary outcomes include procedure times, need for additional therapies or surgery, and detailed defect features post-procedure. The total follow-up duration can extend up to 3 years to fully understand long-term effects and safety.

The Australia and New Zealand Multicentre Upper Gastrointestinal Endoscopic Tissue Resection Study