The Australian Colonic Large Sessile Lesion Endoscopic Resection Study

What this Trial Is About

Researchers are conducting a prospective, multicentre observational study focused on patients referred for endoscopic removal of large sessile colorectal polyps measuring 20 mm or larger. These lesions, known as large sessile lesions (LSL), are found in about 1% of colonoscopies and are more challenging to treat due to their size and higher risk of advanced tissue changes. The study aims to gather extensive data on the technique of Endoscopic Mucosal Resection (EMR), which has emerged as a less invasive alternative to surgery for managing these polyps. The study observes patients undergoing EMR at multiple leading endoscopy centers in Australia. EMR is performed as an outpatient procedure to remove these large polyps, avoiding the need for more invasive surgery. The research collects detailed information about the procedure's effectiveness, safety, complications like bleeding or perforation, and long-term outcomes such as recurrence of the polyps. The study also examines advances in techniques like the use of specific agents for lifting tissue and methods to reduce recurrence. Participants will have their clinical data, procedure details, and outcomes tracked over time, with follow-up extending from 6 up to 60 months. The researchers monitor recurrence rates of the polyps, technical success of the EMR procedures, and the ability to predict cancer presence during the procedure. This long-term observation helps to understand the clinical effectiveness and safety of EMR in treating large sessile colonic lesions, with the goal of improving patient care and treatment strategies.

The Australian Colonic Large Sessile Lesion Endoscopic Resection Study