Study of Anti-Nephrin Autoantibodies in Adults with Idiopathic Nephrotic Syndrome Including MCD, FSGS, and Membranous Nephropathy

What this Trial Is About

Researchers are studying idiopathic nephrotic syndrome INS, which includes minimal change disease MCD and focal segmental glomerulosclerosis FSGS, and comparing it to primary membranous nephropathy MN. The goal is to evaluate the levels of circulating anti-nephrin autoantibodies, which may play a role in INS and post-transplant FSGS relapse. INS is a serious kidney condition with unclear causes and limited treatment options, especially when it recurs after transplantation. The study involves testing stored blood samples from patients with biopsy-confirmed idiopathic MCD or FSGS and those with membranous nephropathy. These samples will be analyzed using specialized ELISA tests to measure anti-nephrin autoantibody levels. The tests use recombinant nephrin protein and antibodies to detect these autoantibodies in the blood, comparing patients with INS to those with MN. Participants have previously provided consent for their samples to be stored in a certified biobank. Researchers will analyze these samples retrospectively over about one year to measure antibody levels. The study focuses on laboratory analysis without direct patient involvement, aiming to better understand the potential role of anti-nephrin autoantibodies in nephrotic syndrome and its recurrence after kidney transplant.

Autoantibodies Against-nephrin in Idiopathic Nephrotic Syndrome