Evaluation of Autogenous Tooth Transplantation Using Simulated Open Apex and Platelet-Rich Fibrin to Improve Healing in Teeth with Fully Formed Roots

What this Trial Is About

Researchers are evaluating autogenous tooth transplantation combined with simulated apical opening and autologous platelet-rich fibrin PRF in patients with complete root formation teeth. This approach aims to improve pulpal revascularization, reduce pulp necrosis, and enhance long-term outcomes for tooth loss cases where implant therapy is not suitable, especially in young patients with ongoing skeletal growth. The study explores a biologically driven method that integrates surgical and regenerative techniques to expand transplantation options. The treatment involves extracting the donor tooth atraumatically, then creating a simulated open apex using rotary instruments to encourage blood vessel regrowth inside the tooth. Autologous PRF, prepared from the patients blood through centrifugation, is applied to the recipient site to support clot formation, tissue regeneration, and healing. The PRF acts as a scaffold to stabilize the clot and promote vascularization before placing the donor tooth into the alveolus. Participants will be monitored at multiple timepoints up to two years post-transplantation. Assessments include checking for tooth resorption, vitality, mobility, inflammation, periodontal health, and bone remodeling. The study tracks healing progress and biological outcomes to evaluate the success of this combined technique. Total participation duration spans at least two years, with evaluations at 1 month, 3 months, 6 months, 1 year, and 2 years after treatment.

Autogenous Tooth Transplantation With Instrumentally Simulated Open Apex and Platelet-Rich Fibrin