Actively Recruiting
Clinical Evaluation of Autogenous Tooth Transplantation With Instrumentally Simulated Open Apex and Autologous Platelet-Rich Fibrin Support in Teeth With Complete Root Formation
Led by University of Bari Aldo Moro · Updated on 2026-02-06
5
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating autogenous tooth transplantation combined with simulated apical opening and autologous platelet-rich fibrin (PRF) in patients with complete root formation teeth. This approach aims to improve pulpal revascularization, reduce pulp necrosis, and enhance long-term outcomes for tooth loss cases where implant therapy is not suitable, especially in young patients with ongoing skeletal growth. The study explores a biologically driven method that integrates surgical and regenerative techniques to expand transplantation options. The treatment involves extracting the donor tooth atraumatically, then creating a simulated open apex using rotary instruments to encourage blood vessel regrowth inside the tooth. Autologous PRF, prepared from the patient's blood through centrifugation, is applied to the recipient site to support clot formation, tissue regeneration, and healing. The PRF acts as a scaffold to stabilize the clot and promote vascularization before placing the donor tooth into the alveolus. Participants will be monitored at multiple timepoints up to two years post-transplantation. Assessments include checking for tooth resorption, vitality, mobility, inflammation, periodontal health, and bone remodeling. The study tracks healing progress and biological outcomes to evaluate the success of this combined technique. Total participation duration spans at least two years, with evaluations at 1 month, 3 months, 6 months, 1 year, and 2 years after treatment.
CONDITIONS
Brief Title
Autogenous Tooth Transplantation With Instrumentally Simulated Open Apex and Platelet-Rich Fibrin
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 10 and 80 years
- Early loss of permanent teeth due to trauma, extensive caries, or agenesis
- Dental agenesis involving premolars or incisors with a suitable donor tooth
- Replacement of non-restorable teeth such as fractures or destructive caries
- Preservation of alveolar bone in growing patients where implants are contraindicated
- Functional and aesthetic rehabilitation of anterior teeth in pediatric and adolescent patients
- Post-traumatic oral rehabilitation in young patients
- Good general and oral health
- Presence of a vital and intact periodontal ligament on the donor tooth
- Adequate recipient site dimensions and morphology or surgically adaptable
- Absence of active infection at the recipient site
- Donor tooth extracted for orthodontic purposes, impacted or erupting third molars with compatible morphology, or suitable supernumerary teeth
You will not qualify if you...
- Poor patient compliance
- Active infection at the recipient site
- Smoking more than 15 cigarettes a day
- Untreated periodontal disease
- Pregnancy or breastfeeding at date of inclusion
- Acute infections
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single surgical procedure with immediate post-operative period
Participants undergo autogenous tooth transplantation with instrumentally simulated open apex and autologous platelet-rich fibrin applied to the recipient site to promote healing and pulpal revascularization.
1 surgical visit (in-person)
Duration - Up to 2 years
Participants are monitored for clinical outcomes including tooth vitality, resorption, mobility, inflammation, periodontal health, and bone remodeling to assess the success of the transplantation.
Visits at 1 month, 3 months, 6 months, 1 year, and 2 years post-transplantation
Trial Site Locations
Total: 1 location
1
University of Bari Aldo Moro, Hospital
Bari, Italy, 70124
Actively Recruiting
Research Team
G
Giuseppe D'Albis, Dr.
N
Nicola De Giglio, Dr.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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