Actively Recruiting
Autoimmune Dementia: Predictors of Neuronal Synaptic Antibodies in Patients With New-ONset Cognitive Impairment
Led by Azienda Usl di Bologna · Updated on 2026-02-11
300
Participants Needed
3
Research Sites
163 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to investigate the frequency and the possible pathogenic role of neuronal synaptic antibodies (NSAb) in patients with cognitive impairment (CI). The main questions it aims to answer are: 1. the frequency and associated features of NSAb in patients with CI and the usefulness of a clinical score in improving autoimmune dementia (AID) diagnosis; 2. the clinical significance of NSAb in patients with CI not fulfilling the autoimmune encephalitis (AE) criteria and serum NSAb (NSAb-pos-CI); 3. the impact of blood-brain-barrier (BBB) dysfunction on their pathogenicity.
CONDITIONS
Official Title
Autoimmune Dementia: Predictors of Neuronal Synaptic Antibodies in Patients With New-ONset Cognitive Impairment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Both sexes
- Adults aged between 40 and 90 years
- Diagnosis of new-onset neurocognitive disorders (major or minor) within the previous 24 months, defined by DSM-5 criteria
You will not qualify if you...
- History of seizures within 4 weeks from onset
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
IRCCS Istituto delle Scienze Neurologiche di Bologna
Bologna, Bologna, Italy, 40139
Actively Recruiting
2
Istituto Auxologico Italiano IRCCS
Milan, Milano, Italy, 20095
Actively Recruiting
3
Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, Milano, Italy, 20133
Actively Recruiting
Research Team
M
Maria Pia Giannoccaro, Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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