Actively Recruiting

Age: 18Years +
All Genders
NCT04119713

Autoimmunity After Checkpoint Blockade

Led by Abramson Cancer Center at Penn Medicine · Updated on 2026-01-08

600

Participants Needed

1

Research Sites

331 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The purpose of this study is to better understand how the treatment of cancer with immune checkpoint inhibitors (ICI) leads to the development of autoimmunity. Specifically, we wish to understand the genetics and immune system features that cause a subset of cancer patients treated with checkpoint inhibitor therapy to develop an immune-related adverse event (irAE).

CONDITIONS

Official Title

Autoimmunity After Checkpoint Blockade

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • A diagnosis of cancer and prescription for a checkpoint inhibitor
Not Eligible

You will not qualify if you...

  • Any subjects not willing or able to give consent
  • Children under the age of 18
  • A history of transplant

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
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3
+1

Trial Site Locations

Total: 1 location

1

University of Pennsylvania - Abramson Cancer Center

Philadelphia, Pennsylvania, United States, 19104

Actively Recruiting

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Research Team

K

Kyra J Sacksith

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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Autoimmunity After Checkpoint Blockade | DecenTrialz