Actively Recruiting
Autologous Cultured Corneal Epithelium (CECA) for the Treatment of Limbal Stem Cell Deficiency
Led by CHU de Quebec-Universite Laval · Updated on 2025-07-10
54
Participants Needed
4
Research Sites
782 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study " Autologous cultured corneal epithelium (CECA) for the treatment of corneal lesions associated with limbal stem cell deficiency" is the first clinical trial of this product manufactured at the LOEX laboratory. The culture of corneal epithelium strives to produce a reconstructed tissue with the therapeutical aim of treatment of limbal stem cell deficiency. The study is a phase I/phase II study with the goal to evaluate safety and efficacy of the CECA graft for the treatment of human patients suffering from limbal stem cell deficiency. The trial is open to all genders. The inclusion of 5 minors is planned.
CONDITIONS
Official Title
Autologous Cultured Corneal Epithelium (CECA) for the Treatment of Limbal Stem Cell Deficiency
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All genders
- Adults
- Minors
- Limbal stem cell deficiency (LSCD) in one or both eyes
- A minimum of 1-3 mm2 of undamaged limbus available for biopsy without harm to the donor eye
You will not qualify if you...
- Donor eye is not healthy enough to safely allow a 1-3 mm2 limbal biopsy
- Pregnancy
- Breast-feeding
- Incapacitated person
- Known allergy to aprotinine (Trasylol)
- Hypersensitivity to bovine proteins
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 4 locations
1
University Health Network - Toronto Western Hospital
Toronto, Ontario, Canada, M5T 2S8
Actively Recruiting
2
CIUSSS de l'Est de l'île de Montréal
Montreal, Quebec, Canada, H1T 2M4
Actively Recruiting
3
McGill University Health Centre; Centre de Médecine Innovatrice/Centre for Innovative Medicine
Montreal, Quebec, Canada
Actively Recruiting
4
Centre universitaire d'Ophtalmologie CHU de Québec - HSS
Québec, Quebec, Canada, G1S 4L8
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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