Actively Recruiting
Autologous Decidual-like Natural Killer Cells Therapy for Infertility or Adverse Pregnancy History
Led by The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Updated on 2025-11-17
14
Participants Needed
1
Research Sites
145 weeks
Total Duration
On this page
Sponsors
T
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Lead Sponsor
T
The University of Science and Technology of China
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this study is preliminary exploration of the effectiveness and duration of autologous decidual-like NK cells therapy in improving uterine NK cells dysfunction.
CONDITIONS
Official Title
Autologous Decidual-like Natural Killer Cells Therapy for Infertility or Adverse Pregnancy History
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Abnormal uterine NK cell function
- History of at least one of the following: unexplained recurrent spontaneous abortions (≥2, including biochemical pregnancy), repeated implantation failure (failure of good-quality embryos in at least two IVF cycles), unexplained infertility, early-onset severe gestational hypertension, or early-onset fetal growth restriction
- Clear desire to conceive
- Normal ovarian function or with frozen embryos
- Endometrium thickness ≥ 7mm measured by vaginal ultrasound before ovulation or at mid-luteal phase
- Body mass index between 18kg/m² and 30kg/m²
You will not qualify if you...
- Use of progesterone receptor modulators
- Chromosomal karyotype abnormalities in one spouse
- Severe endometriosis, uterine fibroids affecting uterine shape or size more than 2.5 months of pregnancy, uterine malformation, uterine adhesion, or thin endometrium
- Uncontrolled autoimmune diseases
- Abnormal blood coagulation, abnormal liver or kidney function, or other uncontrolled basic diseases (hypertension, diabetes, thyroid disease, etc.) that may affect study progress
- History of pelvic malignant tumors
- Currently participating in other clinical studies
- Allergy to blood products
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Affiliated Drum Tower Hospital of Nanjing University
Nanjing, Jiangsu, China, 210006
Actively Recruiting
Research Team
Y
Yali Hu
CONTACT
H
Hui Zhu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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