Actively Recruiting
Autologous Hematopoietic Stem Cell Infusion for Prolonged Cytopenia After CAR-T Cell Therapy
Led by Institute of Hematology & Blood Diseases Hospital, China · Updated on 2025-08-17
20
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective, single-arm, single-center clinical study designed to evaluate the safety of autologous hematopoietic stem cell infusion for the treatment of prolonged cytopenia following CAR-T cell therapy. Approximately 20 patients will be enrolled.
CONDITIONS
Official Title
Autologous Hematopoietic Stem Cell Infusion for Prolonged Cytopenia After CAR-T Cell Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to understand and willingly sign a written informed consent form
- Age 18 years or older
- Diagnosis of multiple myeloma according to International Myeloma Working Group criteria
- Prior CAR-T cell therapy with current remission or refractory/progressive disease not needing salvage therapy
- Presence of grade 3-4 cytopenia (low neutrophils, platelets, or hemoglobin) persisting or newly developed between day 30 and day 90 after CAR-T infusion, or suitable for inclusion by investigator judgment
- Availability of at least 1 million autologous hematopoietic stem cells in reserve
You will not qualify if you...
- Known intolerance, hypersensitivity, or contraindication to autologous hematopoietic stem cell infusion
- Active hepatitis B or hepatitis C infection
- Known HIV infection
- Life expectancy less than 6 months
- Women who are pregnant or breastfeeding
- Evidence of uncontrolled dysfunction of heart, lung, brain, or other important organs
- Any other conditions deemed unsuitable for the trial by the principal investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences
Tianjin, Tianjin Municipality, China
Actively Recruiting
Research Team
G
Gang An, PhD&MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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