Actively Recruiting
Autologous Osteoperiosteal Transplantation for the Treatment of Severe Osteochondral Lesions of the Talus
Led by Peking University Third Hospital · Updated on 2024-08-06
60
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to establish a multicenter prospective cohort of patients with severe osteochondral lesion of the talus (OLT), evaluate the clinical efficacy of autologous osteoperiosteal transplantation and the incidence of postoperative donor-site morbidity. The main questions it aims to answer are: Does autologous osteoperiosteal transplantation have good clinical outcomes in the treatment of severe OLT? Does autologous osteoperiosteal transplantation treat severe OLT with fewer postoperative complications? Participants will: Undergo autologous osteoperiosteal transplantation for OLT Receive clinical follow-up 3, 6, 12, and 24 months after surgery and answer scales of ankle function assessment Take CT and MRI preoperatively and 12 and 24 months after surgery
CONDITIONS
Official Title
Autologous Osteoperiosteal Transplantation for the Treatment of Severe Osteochondral Lesions of the Talus
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Chronic ankle pain diagnosed as Osteochondral Lesions of the Talus (OLT)
- Hepple V OLT on the medial side of the talus or lesion diameter 2 8 mm
- Symptoms not relieved after at least 3 months of conservative treatment
- Willing to voluntarily participate and sign informed consent
You will not qualify if you...
- Varus or valgus ankle deformity greater than 5 degrees
- Grade III injury of the lateral collateral ligament of the ankle
- Chronic synovitis such as rheumatoid arthritis or pigmented villous nodular synovitis
- Joint fibrosis, stiffness, or significantly restricted range of motion
- Moderate to severe knee osteoarthritis seen on plain radiographs
- Failure to complete required rehabilitation protocol
- Medically unfit for surgery, radiographs, or MRI
- Women who are pregnant, planning pregnancy, or lactating
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Peking University Third Hospital
Beijing, China
Actively Recruiting
Research Team
Q
Qinwei Guo, MD
CONTACT
Q
Qixian Shen, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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