Multicenter Study of Autologous Osteoperiosteal Transplantation for Severe Osteochondral Lesions of the Talus in Adults

What this Trial Is About

Researchers are conducting a multicenter prospective cohort study to evaluate the clinical results and safety of autologous osteoperiosteal transplantation in patients with severe osteochondral lesions of the talus OLT. The study aims to determine whether this procedure provides good clinical outcomes and fewer postoperative complications when treating severe OLT. This study is sponsored by Peking University Third Hospital. Participants will undergo autologous osteoperiosteal transplantation, where a bone graft is taken from the iliac crest and transplanted to repair the lesion in the talus. The surgical procedure involves drilling and debriding the cystic lesion before grafting bone tissue. The study includes clinical follow-up visits at 3, 6, 12, and 24 months after surgery, with imaging examinations such as CT and MRI performed before surgery and at 12 and 24 months post-operation. During the study, participants will complete ankle function assessments including the Foot and Ankle Outcome Score FAOS at multiple time points up to 24 months after surgery. Additional measures include the American Orthopedic Foot and Ankle Society Score, Visual Analogue Scale for pain, Ankle Activity Score, and cartilage repair imaging assessments. Complications will be monitored up to 48 months after surgery to evaluate safety and donor-site morbidity. Participants will be closely followed to assess recovery and clinical outcomes over this period.

Autologous Osteoperiosteal Transplantation for the Treatment of Severe Osteochondral Lesions of the Talus