Study of Transplanting Previously Frozen Ovarian Tissue to Treat Female Infertility Following Chemotherapy or Radiation

What this Trial Is About

This research aims to evaluate the safety and effectiveness of transplanting a womans own previously frozen ovarian tissue to treat primary ovarian insufficiency caused by chemotherapy andor radiation treatments. The study focuses on women experiencing infertility due to these cancer therapies and examines how autologous ovarian tissue transplantation may restore ovarian function and fertility. Participants will undergo thawing and surgical transplantation of their cryopreserved ovarian cortical tissue into the abdomen through laparoscopy or minilaparotomy. The study includes a screening visit with fertility consultation and testing, followed by the transplantation procedure. After surgery, there are multiple follow-up visits within the first two years to monitor hormone levels, menstrual function, surgical recovery, and pregnancy status. Starting three years after transplantation, participants receive annual surveys regarding reproductive health and any medical changes. Throughout the study, participants complete assessments such as blood tests measuring reproductive hormones, vaginal ultrasounds, and quality of life surveys related to fertility. Researchers will track outcomes including hormone changes, return of regular menstruation, and pregnancy success up to 15 years. Safety monitoring includes checking for cancer recurrence and surgical complications. Overall participation may last up to 15 years, with ongoing follow-up to gather long-term data on fertility and health.

Autologous Ovarian Tissue Transplantation