Comparing Two Gum Surgery Treatments for Periodontal Bone Defects Using Patients Own Platelet Concentrate or Animal-Derived Bone Grafts in Adults Aged 25 to 80

What this Trial Is About

Researchers are studying patients with gum disease periodontitis to compare two types of minor gum surgery that aim to reduce the depth of gum pockets and regenerate damaged bone and gum tissue. This randomized, single-blind clinical trial follows established standards and will include 74 adults aged 25 to 80 years who are otherwise healthy and affected by periodontitis with specific intrabony defects. Participants will be randomly assigned to one of two treatments a procedure using a product made from their own blood called PRGF ENDORET combined with a Simplified Papilla Preservation Flap SPPF, or a surgery using a bone graft and collagen membrane from animal sources also combined with SPPF. The study includes nine visits over at least 13 months, starting with baseline assessments, followed by surgery within six weeks, and several follow-up visits at 2 days, 7 days, 14 days, 4 weeks, 3 months, 6 months, and 12 months after surgery. During the study, participants will undergo various assessments including periodontal measurements, intra-oral and extra-oral 3D scans, thermal scans, laser imaging, and questionnaires about quality of life and treatment impact. An intra-oral X-ray is taken before surgery and after 12 months to evaluate bone regeneration. Researchers will monitor healing, patient-reported outcomes, swelling, blood flow changes, and radiographic bone changes throughout the study period.

Autologous Platelet Concentrate (APC) in Intrabony Defects