Actively Recruiting
Autologous Platelet-Rich Plasma Intra-ovarian Infusion in Poor Responders
Led by Genesis Athens Clinic · Updated on 2024-12-27
100
Participants Needed
1
Research Sites
329 weeks
Total Duration
On this page
Sponsors
G
Genesis Athens Clinic
Lead Sponsor
N
National and Kapodistrian University of Athens
Collaborating Sponsor
AI-Summary
What this Trial Is About
Autologous PRP intra ovarian infusion may improve ovarian response, patients' hormonal profile as well as fresh embryo transfer (ET)-ICSI cycles' outcome in patients presenting with Poor Ovarian Response (POR).
CONDITIONS
Official Title
Autologous Platelet-Rich Plasma Intra-ovarian Infusion in Poor Responders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Poor Ovarian Response according to Bologna Criteria (fulfilling 2 out of 3 criteria)
- Age 40 years or older
- AMH less than 1.1 ng/ml OR Antral Follicle Count (AFC) less than 7
- Three or fewer oocytes retrieved with conventional stimulation protocol
- Stopped any supportive treatments including hormone replacement, acupuncture, or botanotherapy for at least three months before recruitment
- Willing to comply with study requirements
You will not qualify if you...
- Any pathological disorder related to reproductive system anatomy
- Irregular menstrual cycles
- Amenorrhea
- Endometriosis
- Adenomyosis
- Fibroids and adhesions
- Infections in the reproductive system
- Current or previous cancer diagnosis in the reproductive system
- Family history of reproductive system cancer
- Severe male factor infertility
- Prior referral for preimplantation genetic testing (PGT)
- Ovarian inaccessibility
- Endocrinological disorders such as hypothalamus-pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome
- Body mass index (BMI) greater than 30 kg/m2 or less than 18.5 kg/m2
- Systemic autoimmune disorders
AI-Screening
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Trial Site Locations
Total: 1 location
1
Genesis AC
Athens, Greece, 15232
Actively Recruiting
Research Team
M
Mara Simopoulou, PhD
CONTACT
A
Agni Pantou, MD, PhD Candidate
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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