Treatment of Persistent Corneal Epithelial Defects Using Autologous Platelet-rich Plasma with Bandage Contact Lens Compared to Lubricants and Eye Patch

What this Trial Is About

This research aims to compare different treatments for persistent epithelial defects PED, which are corneal ulcers that do not heal within two weeks despite standard care. These ulcers result from missing substances in tears that normally help corneal healing, and the condition can worsen in diseases like diabetes. The study will evaluate whether autologous platelet-rich plasma PRP with a bandage contact lens heals PED faster than preservative-free lubricant with a bandage contact lens or eye patch with ocular lubricant ointment. Participants will be randomly assigned to one of three treatment groups PRP eye drops with a bandage contact lens every 1 to 3 hours, preservative-free lubricant eye drops with a bandage contact lens every 1 to 3 hours, or an eye patch with ocular lubricant ointment applied every 24 hours. Treatments will continue until the corneal defect fully heals. If the ulcer worsens to corneal thinning or perforation, appropriate medical care will be provided. During the study, healing time will be closely monitored with assessments up to three months, including corneal sensitivity, visual acuity, ocular pain, surface symptoms, and quality of life. Researchers will also track adverse events, recurrences, and treatment failures. Weekly evaluations or sooner if needed will help measure progress, ensuring participant safety and thorough monitoring throughout the treatment period.

Autologous Platelet-rich Plasma in the Treatment of Persistent Epithelial Defects