Evaluating Visual and Anatomical Results of Using Your Own Tenons Capsule Tissue to Treat Difficult Macular Holes

What this Trial Is About

This research aims to evaluate the anatomical and functional outcomes of using autologous Tenons capsule grafting in patients with difficult-to-treat full-thickness macular holes. The study focuses on patients with chronic large macular holes larger than 400 micrometers or persistent holes after previous vitrectomy surgery with membrane peeling and gas tamponade. The purpose is to assess how well the macular holes close anatomically and how visual acuity improves over a three-month follow-up period. Participants will receive a surgical procedure involving a 23-gauge pars plana vitrectomy. During surgery, autologous Tenons capsule tissue will be harvested from the patients own eye, trimmed, and placed into the macular hole. Perfluorocarbon liquid may be used to help stabilize the graft, and silicone oil will be applied as a tamponade to support healing. Silicone oil removal is planned between 8 to 12 weeks after surgery. Throughout the study, researchers will monitor anatomical closure of the macular hole using spectral-domain optical coherence tomography and measure functional changes by testing best-corrected visual acuity at baseline, one month, and three months after surgery. The study includes evaluations of ocular health, fixation ability, and visual recovery over the three-month follow-up. The total participation duration corresponds to this postoperative monitoring period.

Autologous Tenon's Capsule Graft for Refractory Macular Holes