Actively Recruiting
Autologous Testicular Tissue Transplantation
Led by Universitair Ziekenhuis Brussel · Updated on 2026-04-23
5
Participants Needed
1
Research Sites
309 weeks
Total Duration
On this page
Sponsors
U
Universitair Ziekenhuis Brussel
Lead Sponsor
V
Vrije Universiteit Brussel
Collaborating Sponsor
AI-Summary
What this Trial Is About
Freezing testicular tissue of prepubertal boys is a method for preserving spermatogonial stem cells in case of imminent gonadotoxic treatment during childhood. In case of total azoospermia or absence of spermatozoa that can be used for intra-cytoplasmic injection (ICSI) in adulthood, the investigators intend to perform the first in men autologous testicular tissue transplantation to restore fertility.
CONDITIONS
Official Title
Autologous Testicular Tissue Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must have opted as a prepubertal boy to enroll in a fertility preservation program and had testicular tissue cryopreserved after cancer or hematological diagnosis with parental consent
- At least 18 years old
- If female partner exists, she must be younger than 43 years
- No sperm suitable for intra-cytoplasmic sperm injection (ICSI) on two semen analyses
- Normal results from standardized preliminary and preoperative blood tests
- Complete remission of cancer or hematologic disease
- Approval from treating oncologist or specialist if non-oncological disease was reason for tissue preservation
- Negligible risk of malignant cells in testicular tissue based on multidisciplinary assessment
- Presence of spermatogonial stem cells confirmed in at least one thawed tissue fragment
- Written informed consent for transplantation, follow-up, and future children born after the procedure
You will not qualify if you...
- Risk of malignant cells present in testicular tissue
- Contraindication for surgery
- Contraindication for pregnancy in female partner
- Body mass index (BMI) above 32
- Heavy smoking (10 or more cigarettes per day)
- Unstable psychological condition
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
UZ Brussel Centre for Reproductive Medicine
Brussels, Belgium, 1090
Actively Recruiting
Research Team
V
Veerle Vloeberghs, MD
CONTACT
H
Herman Tournaye, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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